ArticleEnvironmental health perspectives2001
Increased risk of malignant mesothelioma of the pleura after residential or domestic exposure to asbestos: a case-control study in Casale Monferrato, Italy.
Article in Environmental health perspectives, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 4 of them syntheses that pooled it.
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45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 159 citations in OpenAlex.
- Brazilian Thoracic Society recommendations for the diagnosis and monitoring of asbestos-exposed individuals.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2024Guideline
- Methodological issues in descriptive environmental epidemiology. The example of study Sentieri.La Medicina del lavoro · 2021Pooled it
- Association between mesothelioma and non-occupational asbestos exposure: systematic review and meta-analysis.Environmental health : a global access science source · 2018Pooled it
- Domestic asbestos exposure: a review of epidemiologic and exposure data.International journal of environmental research and public health · 2013Pooled it
- The evolution of an epidemic: age-period-cohort modelling of mesothelioma in Casale Monferrato, 1990-2021, with projections to 2042.Environmental health : a global access science source · 2025Article
- Challenges in defining thresholds for health effects: some considerations for asbestos and silica.Frontiers in epidemiology · 2025Review
- Pleural mesothelioma from fluoro-edenite exposure: PACAP and PAC1 receptor. A preliminary report.European journal of histochemistry : EJH · 2024Article
- Association of mesothelioma deaths with neighborhood asbestos exposure due to a large-scale asbestos-cement plant.Cancer science · 2023Article
- The Epidemiological Surveillance of Mesothelioma Mortality in Italy as a Tool for the Prevention of Asbestos Exposure.International journal of environmental research and public health · 2023Article
- The Italian Experience in the Development of Mesothelioma Registries: A Pathway for Other Countries to Address the Negative Legacy of Asbestos.International journal of environmental research and public health · 2023Article
- An Approach to Overcome the Limitations of Surveillance of Asbestos Related Diseases in Low- and Middle-Income Countries: What We Learned from the Sibaté Study in Colombia.Annals of global health · 2023Article
- Pleural mesothelioma risk by industry and occupation: results from the Multicentre Italian Study on the Etiology of Mesothelioma (MISEM).Environmental health : a global access science source · 2022Article
- Public health risks from asbestos cement roofing.American journal of industrial medicine · 2022Article
- A Cohort Study on Cancer Incidence among Women Exposed to Environmental Asbestos in Childhood with a Focus on Female Cancers, including Breast Cancer.International journal of environmental research and public health · 2022Article
- Environmental asbestos exposure and clustering of malignant mesothelioma in community: a spatial analysis in a population-based case-control study.Environmental health : a global access science source · 2021Article
- Ascertainment Bias in a Historic Cohort Study of Residents in an Asbestos Manufacturing Community.International journal of environmental research and public health · 2021Article
- Evaluation of Nonresponse Bias in a Case-Control Study of Pleural Mesothelioma.International journal of environmental research and public health · 2020Article
- Psychological Distress after a Diagnosis of Malignant Mesothelioma in a Group of Patients and Caregivers at the National Priority Contaminated Site of Casale Monferrato.International journal of environmental research and public health · 2020Article
- Asbestos Air Pollution: Description of a Mesothelioma Cluster Due to Residential Exposure from an Asbestos Cement Factory.International journal of environmental research and public health · 2020Article
- Mesothelioma developing in carriers of inherited genetic mutations.Translational lung cancer research · 2020Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association of malignant mesothelioma (MM) and nonoccupational asbestos exposure is currently debated. Our study investigates environmental and domestic asbestos exposure in the city where the largest Italian asbestos cement (AC) factory was located. This population-based case-control study included pleural MM (histologically diagnosed) incidents in the area in 1987-1993, matched by age and sex to two controls (four if younger than 60). Diagnoses were confirmed by a panel of five pathologists. We interviewed 102 cases and 273 controls in 1993-1995, out of 116 and 330 eligible subjects. Information was checked and completed on the basis of factory and Town Office files. We adjusted analyses for occupational exposure in the AC industry. In the town there were no other relevant industrial sources of asbestos exposure. Twenty-three cases and 20 controls lived with an AC worker [odds ratio (OR) = 4.5; 95% confidence interval (CI), 1.8-11.1)]. The risk was higher for the offspring of AC workers (OR = 7.4; 95% CI, 1.9-28.1). Subjects attending grammar school in Casale also showed an increased risk (OR = 3.3; 95% CI, 1.4-7.7). Living in Casale was associated with a very high risk (after selecting out AC workers: OR = 20.6; 95% CI, 6.2-68.6), with spatial trend with increasing distance from the AC factory. The present work confirms the association of environmental asbestos exposure and pleural MM, controlling for other sources of asbestos exposure, and suggests that environmental exposure caused a greater risk than domestic exposure.
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