ArticleThe Biochemical journal2001
The shorter zinc finger protein ZNF230 gene message is transcribed in fertile male testes and may be related to human spermatogenesis.
Article in The Biochemical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Zinc as a Modulator of Male Fertility: Interplay Between Lipid Metabolism, Oxidative Stress, and Sperm Function.Biological trace element research · 2025Review
- Comparative transcriptome analysis of bull X- and Y-spermatozoa.Scientific reports · 2025Article
- Navigating the Challenges of Gluten Enteropathy and Infertility: The Role of Celiac-Related Antibodies and Dietary Changes.Antibodies (Basel, Switzerland) · 2023Review
- Mitochondrial Pseudogenes Suggest Repeated Inter-Species Hybridization among Direct Human Ancestors.Genes · 2022Article
- Comparative Analysis of Testicular Histology and lncRNA-mRNA Expression Patterns Between Landes Geese (Frontiers in genetics · 2021Article
- Altered Gene Expression in the Testis of Infertile Patients with Nonobstructive Azoospermia.Computational and mathematical methods in medicine · 2021Article
- The zinc finger domain of RING finger protein 141 reveals a unique RING fold.Protein science : a publication of the Protein Society · 2017Article
- Targeted disruption of the mouse testis-enriched gene Znf230 does not affect spermatogenesis or fertility.Genetics and molecular biology · 2014Article
- KRAB-Zinc Finger Proteins: A Repressor Family Displaying Multiple Biological Functions.Current genomics · 2013Article
- Germinal Cell Aplasia in Kif18a Mutant Male Mice Due to Impaired Chromosome Congression and Dysregulated BubR1 and CENP-E.Genes & cancer · 2010Article
- DAZL binds to 3'UTR of Tex19.1 mRNAs and regulates Tex19.1 expression.Molecular biology reports · 2009Article
- Molecular cloning and expression analysis of a zebrafish novel zinc finger protein gene rnf141.Genetics and molecular biology · 2009Article
- Spermatogenesis-related ring finger gene ZNF230 promoter: identification and functional analysis.Molecular biology reports · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The zinc finger gene family represents one of the largest in the mammalian genome, with several of these genes reported to be involved in spermatogenesis. A newly discovered gene has been identified that is expressed abundantly in the testicular tissue of fertile men as determined by mRNA differential display. The gene encodes a C(3)HC(4)-type zinc finger protein motif (ring finger motif) consistent with a role in pre-meiotic or post-meiotic sperm development. The gene was named ZNF230 and mapped to the short arm of chromosome 11 (11p15). ZNF230 has two transcripts, of 1 kb and 4.4 kb in length. The shorter 1 kb transcript was only detected in testicular tissue whereas the longer 4.4 kb transcript was not detected in testis but was found in several other tissues. The lack of detectable ZNF230 expression in azoospermic patients by reverse transcriptase-mediated PCR analysis is interpreted to mean that this gene is involved in maintaining normal human male fertility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.