ReviewRespiratory research2000
Hypoxic pulmonary vasoconstriction: role of voltage-gated potassium channels.
Review in Respiratory research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 119 citations in OpenAlex.
- The Role of Ion Channels in Pulmonary Hypertension: A Review.Pulmonary circulation · 2025Review
- Article
- Use of FRET-Sensor 'Mermaid' to Detect Subtle Changes in Membrane Potential of Primary Mouse PASMCs.Cells · 2024Article
- Nicardipine-induced acute respiratory failure: Case report and literature review.Clinical case reports · 2023Article
- Health-Screening-Based Chronic Obstructive Pulmonary Disease and Its Effect on Cardiovascular Disease Risk.Journal of clinical medicine · 2022Article
- TRPC6, a therapeutic target for pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Effects of bevacizumab administration on the hypoxia - induced pulmonary hypertension rat model.Turkish journal of medical sciences · 2021Article
- Biochemical and physiological properties of KChemico-biological interactions · 2019Review
- Hypoxic Pulmonary Vasoconstriction in Humans: Tale or Myth.The open cardiovascular medicine journal · 2017Review
- AMP-activated protein kinase inhibits Kv 1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation.The Journal of physiology · 2016Article
- Targeted inhibition of survivin with YM155 promotes apoptosis of hypoxic human pulmonary arterial smooth muscle cells via the upregulation of voltage-dependent K⁺ channels.Molecular medicine reports · 2016Article
- Ca(2+) and ion channels in hypoxia-mediated pulmonary hypertension.International journal of clinical and experimental pathology · 2015Review
- Oxidative modulation of voltage-gated potassium channels.Antioxidants & redox signaling · 2014Review
- Disappearance of hypoxic pulmonary vasoconstriction and o2-sensitive nonselective cationic current in arterial myocytes of rats under ambient hypoxia.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2013Article
- Signal transduction in the development of pulmonary arterial hypertension.Pulmonary circulation · 2013Review
- Hypoxia induces voltage-gated K+ (Kv) channel expression in pulmonary arterial smooth muscle cells through hypoxia-inducible factor-1 (HIF-1).Bosnian journal of basic medical sciences · 2012Article
- Endothelial and smooth muscle cell ion channels in pulmonary vasoconstriction and vascular remodeling.Comprehensive Physiology · 2011Review
- STIM2 Contributes to Enhanced Store-operated Ca Entry in Pulmonary Artery Smooth Muscle Cells from Patients with Idiopathic Pulmonary Arterial Hypertension.Pulmonary circulation · 2011Article
- Hypoxia-induced changes in pulmonary and systemic vascular resistance: where is the O2 sensor?Respiratory physiology & neurobiology · 2010Review
- Sex hormones and vascular protection in pulmonary arterial hypertension.Journal of cardiovascular pharmacology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Activity of voltage-gated potassium (Kv) channels controls membrane potential, which subsequently regulates cytoplasmic free calcium concentration ([Ca2+]cyt) in pulmonary artery smooth muscle cells (PASMCs). Acute hypoxia inhibits Kv channel function in PASMCs, inducing membrane depolarization and a rise in [Ca2+ ]cyt that triggers vasoconstriction. Prolonged hypoxia inhibits expression of Kv channels and reduces Kv channel currents in PASMCs. The consequent membrane depolarization raises [Ca2+]cyt, thus stimulating PASMC proliferation. The present review discusses recent evidence for the involvement of Kv channels in initiation of hypoxic pulmonary vasoconstriction and in chronic hypoxia-induced pulmonary hypertension.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.