ReviewRespiratory research2000
The gene encoding interleukin-13: a susceptibility locus for asthma and related traits.
Review in Respiratory research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Interleukin-13 gene polymorphisms and asthma susceptibility in children: a meta-analysis.BMC pediatrics · 2025Pooled it
- Cross-scale genetic analysis prioritizes shared regulatory variation, cell-type contributions, co-expression programs, and exon-level patterns in atopic dermatitis and asthma.Functional & integrative genomics · 2026Article
- Small extracellular vesicle signaling and mitochondrial transfer reprogram T helper cell function in human asthma.Nature communications · 2026Article
- The therapeutic potential of vitamin D supplementation in asthma.Pharmacological reports : PR · 2025Review
- Anti-asthmatic fraction screening and mechanisms prediction of Schisandrae Sphenantherae Fructus based on a combined approach.Frontiers in pharmacology · 2022Article
- Glucocorticoids-All-Rounders Tackling the Versatile Players of the Immune System.Frontiers in immunology · 2019Review
- Anti-inflammatory Effect of Alloferon on Ovalbumin-induced Asthma.Immune network · 2015Article
- Allergenicity and toxicology of inhaled silver nanoparticles in allergen-provocation mice models.International journal of nanomedicine · 2013Article
- Asthmatic airway epithelium is intrinsically inflammatory and mitotically dyssynchronous.American journal of respiratory cell and molecular biology · 2011Article
- Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma.European respiratory review : an official journal of the European Respiratory Society · 2010Review
- Interleukin13 haplotypes and susceptibility of Iranian women to breast cancer.Molecular biology reports · 2009Article
- Lack of association between interleukin-13 gene polymorphisms (-1055 C/T and +2044 G/A) in Iranian patients with lung cancer.Molecular biology reports · 2009Article
- Altered regulation of aquaporin gene expression in allergen and IL-13-induced mouse models of asthma.Cytokine · 2009Article
- New insights into the pathogenesis and genetics of psoriatic arthritis.Nature clinical practice. Rheumatology · 2009Review
- The IL-1 type 1 receptor is required for the development of LPS-induced airways disease.The Journal of allergy and clinical immunology · 2007Article
- Microarray profiling of lymphocytes in internal diseases with an altered immune response: potential and methodology.Mediators of inflammation · 2005Review
- Association study of autoimmune thyroid disease at 5q23-q33 in Japanese patients.Journal of human genetics · 2003Article
- The shape of the messenger: using protein structure information to design novel cytokine-based therapeutics.Current pharmaceutical design · 2002Review
- Susceptibility genes in asthma and allergy.Current allergy and asthma reports · 2001Review
- Th2 cytokines and asthma: an introduction.Respiratory research · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma is a complex inflammatory disorder controlled by both genetic and environmental influences. Multiple genetic analyses have identified the T helper type 2 (Th2) cytokine gene cluster on chromosome 5q as a susceptibility locus for asthma. Recently, the Th2 cytokine interleukin-13 has been shown to be a critical mediator of the asthma phenotype in murine models. In this commentary we discuss several recent studies that have identified polymorphisms in the gene encoding interleukin-13. The consistent genetic associations of interleukin-13 with asthma and related traits across diverse ethnic populations in these studies provides strong support for the candidacy of this cytokine as a susceptibility locus for asthma and atopy on chromosome 5q31.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.