ArticleJournal of molecular neuroscience : MN2001
Changes in neuronal acetylcholinesterase gene expression and division of labor in honey bee colonies.
Article in Journal of molecular neuroscience : MN, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 86 citations in OpenAlex.
- Morphometric and Biochemical Parameters ofVeterinary sciences · 2026Article
- Article
- Comprehension of the age-dependent gut and brain interaction of honey bee workers by integration of multi omics approaches.Journal of advanced research · 2026Article
- Behavioral and genetic correlates of heterogeneity in learning performance in individual honeybees, Apis mellifera.PloS one · 2024Article
- Brain Gene Expression of Foraging Behavior and Social Environment in Ceratina calcarata.Genome biology and evolution · 2023Article
- Honey bees increase their foraging performance and frequency of pollen trips through experience.Scientific reports · 2019Article
- Identification of the neurotransmitter profile of AmFoxP expressing neurons in the honeybee brain using double-label in situ hybridization.BMC neuroscience · 2018Article
- Article
- Relationship between brain plasticity, learning and foraging performance in honey bees.PloS one · 2018Article
- Expression of acetylcholinesterase 1 is associated with brood rearing status in the honey bee, Apis mellifera.Scientific reports · 2017Article
- RNAi-mediated mortality of the whitefly through transgenic expression of double-stranded RNA homologous to acetylcholinesterase and ecdysone receptor in tobacco plants.Scientific reports · 2016Article
- Measurements of Chlorpyrifos Levels in Forager Bees and Comparison with Levels that Disrupt Honey Bee Odor-Mediated Learning Under Laboratory Conditions.Journal of chemical ecology · 2016Article
- Increased Acetylcholinesterase Expression in Bumble Bees During Neonicotinoid-Coated Corn Sowing.Scientific reports · 2015Article
- Acute exposure to a sublethal dose of imidacloprid and coumaphos enhances olfactory learning and memory in the honeybee Apis mellifera.Invertebrate neuroscience : IN · 2013Article
- Biochemical properties, expression profiles, and tissue localization of orthologous acetylcholinesterase-2 in the mosquito, Anopheles gambiae.Insect biochemistry and molecular biology · 2013Article
- Cholinergic pesticides cause mushroom body neuronal inactivation in honeybees.Nature communications · 2013Article
- Exposure to acetylcholinesterase inhibitors alters the physiology and motor function of honeybees.Frontiers in physiology · 2013Article
- Molecular and kinetic properties of two acetylcholinesterases from the western honey bee, Apis mellifera.PloS one · 2012Article
- Muscarinic regulation of Kenyon cell dendritic arborizations in adult worker honey bees.Arthropod structure & development · 2011Article
- Inactivation of an invertebrate acetylcholinesterase by sulfhydryl reagents: a reconsideration of the implications for insecticide design.Chemico-biological interactions · 2008Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Division of labor in honey bee colonies is highlighted by adult bees making a transition at 2-3 wk of age from working in the hive to foraging for nectar and pollen outside. This behavioral development involves acquisition of new tasks that may require advanced learning capabilities. Because acetylcholinesterase (AChE) hydrolyzes acetylcholine, a major neurotransmitter associated with learning in the insect brain, we searched for changes in AChE expression in the brain during bee behavioral development. Biochemical aspects of the AChE protein were similar in foragers and "nurse" bees that work in the hive tending brood. However, catalytic AChE activity was significantly lower in foragers. Cloning of bee AChE cDNA enabled mRNA analysis, which demonstrated that the forager-related decrease in AChE activity was associated with decreased AChE mRNA levels. This was particularly apparent in the mushroom bodies, a brain region known to be involved with olfactory and visual learning and memory. In addition, treatment with the AChE-inhibitor metrifonate improved performance in an olfactory-learning assay. These findings demonstrate long-term, naturally occurring developmental downregulation of AChE gene expression in the bee brain, and suggest that this genomic plasticity can contribute to facilitated learning capabilities in forager bees.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.