Trial reportEuropean journal of clinical nutrition2001
The effect of meals rich in thermally stressed olive and safflower oils on postprandial serum paraoxonase activity in patients with diabetes.
Trial report in European journal of clinical nutrition, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- PON1 and Mediterranean Diet.Nutrients · 2015Pooled it
- High-Density Lipoprotein Metabolism and Function in Cardiovascular Diseases: What about Aging and Diet Effects?Nutrients · 2024Review
- Factors associated to serum paraoxonase 1 activity in patients with cardiovascular disease.Archives of endocrinology and metabolism · 2021Article
- CYP/PON genetic variations as determinant of organophosphate pesticides toxicity.Journal of genetics · 2017Review
- The PBMC transcriptome profile after intake of oxidized versus high-quality fish oil: an explorative study in healthy subjects.Genes & nutrition · 2016Article
- Dietary fatty acid intake is associated with paraoxonase 1 activity in a cohort-based analysis of 1,548 subjects.Lipids in health and disease · 2013Article
- Pharmacogenetics of paraoxonase activity: elucidating the role of high-density lipoprotein in disease.Pharmacogenomics · 2013Review
- Serum paraoxonase 1 activity is associated with fatty acid composition of high density lipoprotein.Disease markers · 2013Article
- Dietary cholesterol increases paraoxonase 1 enzyme activity.Journal of lipid research · 2012Article
- The human paraoxonase gene cluster as a target in the treatment of atherosclerosis.Antioxidants & redox signaling · 2012Review
- Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: the hunt goes on.Biochemical pharmacology · 2011Review
- Paraoxonase 1 polymorphisms and risk of myocardial infarction in women and men.Circulation journal : official journal of the Japanese Circulation Society · 2009Article
- Mediterranean diet and mild cognitive impairment.Archives of neurology · 2009Article
- Mediterranean diet, Alzheimer disease, and vascular mediation.Archives of neurology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the effects of meals rich in thermally stressed safflower (TSAF) and olive (TSOL) oils on postprandial serum paraoxonase (PON1) arylesterase activity and low density lipoprotein (LDL) oxidation in patients with type 2 diabetes.
designA randomised cross-over study.
settingDiabetes clinic and general practice. SUBJECTS: Fourteen patients (six men and eight women) with type 2 diabetes, aged 48-67 y, glycated haemoglobin <10% and fasting blood glucose <11 mmol/l were recruited.
interventionsPatients received a milkshake rich in TSAF or TSOL and at least a week later they received the alternate milkshake. These fats contained high levels of lipid oxidation and degradation products. Blood samples were taken fasted and 4 h after consumption of the milkshake.
main outcome measuresSerum PON1 activity and lag time in LDL oxidation.
resultsAfter the meal rich in TSOL, serum PON1 activity increased significantly in women (12 (2.22) micromol/ml/min, mean (95% confidence interval), P=0.03) and not in men (0 (-4.4) micromol/ml/min) during the postprandial period. The increase in PON1 activity after the TSOL meal was significantly (P=0.03) greater in women compared with men. In women, the increase in serum PON1 activity after the TSOL meal was significantly different (13 (1.25) micromol/ml/min, P=0.04) compared with the corresponding change (-1 micromol/ml/min) after the TSAF meal. The lag time in LDL oxidation and indices of oxidative stress and antioxidant capacity did not vary significantly during the meals.
conclusionsMeals rich in TSOL may increase postprandial serum PON1 activity in middle-aged and older diabetic women. This change is potentially anti-atherogenic and may favour the use of olive oil over polyunsaturated fats in the diet of patients with type 2 diabetes. SPONSORSHIP: The study was supported by a grant from the National Heart Foundation of New Zealand.
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