Trial reportThorax2001
Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers.
Trial report in Thorax, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Association between the IL1B, IL1RN polymorphisms and COPD risk: a meta-analysis.Scientific reports · 2014Pooled it
- The contribution of genetic factors to thrombotic and bleeding outcomes in coronary patients randomised to IIb/IIIa antagonists.The pharmacogenomics journal · 2002Trial
- Th22 Cells/IL-22 Serves as a Protumor Regulator to Drive Poor Prognosis through the JAK-STAT3/MAPK/AKT Signaling Pathway in Non-Small-Cell Lung Cancer.Journal of immunology research · 2022Article
- Association of IL1 beta gene polymorphism and allograft functions in renal transplant recipients :a case control study from Kashmir Valley.BMC nephrology · 2017Article
- Role of oxidative stress & transient receptor potential in chronic obstructive pulmonary disease.The Indian journal of medical research · 2015Review
- Associations of interleukin-1 gene cluster polymorphisms with C-reactive protein concentration and lung function decline in smoking-induced chronic obstructive pulmonary disease.International journal of clinical and experimental pathology · 2015Article
- Genetic polymorphisms of surfactant protein D rs2243639, Interleukin (IL)-1β rs16944 and IL-1RN rs2234663 in chronic obstructive pulmonary disease, healthy smokers, and non-smokers.Molecular diagnosis & therapy · 2014Article
- Article
- Gene polymorphisms and chronic obstructive pulmonary disease.Journal of cellular and molecular medicine · 2014Article
- Association of cytokine gene polymorphisms in patients with chronic obstructive pulmonary disease.Oman medical journal · 2012Article
- Updates on the COPD gene list.International journal of chronic obstructive pulmonary disease · 2012Review
- Role of P2X7 Receptors in Release of IL-1β: A Possible Mediator of Pulmonary Inflammation.Tanaffos · 2012Review
- Effect of gene environment interactions on lung function and cardiovascular disease in COPD.International journal of chronic obstructive pulmonary disease · 2011Article
- Proinflammatory cytokines in Egyptian elderly with chronic obstructive pulmonary disease.Lung India : official organ of Indian Chest Society · 2010Article
- Pharmacogenetics of chronic obstructive pulmonary disease: challenges and opportunities.Pharmacogenomics · 2010Review
- Article
- Higher genetic susceptibility to inflammation in mild disease activity of systemic lupus erythematosus.Rheumatology international · 2009Article
- IL1B polymorphisms modulate cystic fibrosis lung disease.Pediatric pulmonology · 2009Article
- Gene polymorphisms of IL-6(-174) G/C and IL-1Ra VNTR in asthmatic children.Indian journal of pediatrics · 2008Article
- Understanding genomics: implications for the emergency medicine physician and the treatment of asthma.Pediatric emergency care · 2006Review
Corrections and comments
- Commented on by
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThere is increasing evidence that the cytokine network is central to the immunopathology of inflammatory airway diseases. The interleukin 1 (IL-1) receptor antagonist (IL-1RN) is a naturally occurring anti-inflammatory agent that binds to the IL-1 receptor but does not possess agonist activity. Each of the genes of the IL-1 locus on chromosome 2q14 is polymorphic. The IL1RN gene contains an 86 bp tandem repeat and allele 2 of this polymorphism has been associated with various inflammatory diseases. The IL-1beta (IL1B) gene contains a promoter polymorphism (C-511T) that has been associated with inflammatory diseases and is in linkage disequilibrium with the IL1RN polymorphism.
methodsWe investigated whether polymorphisms in the IL1B and IL1RN genes were associated with rate of decline of lung function. Genotypes were determined in 284 smokers with a rapid decline in lung function and 306 smokers with no decline in lung function.
resultsNone of the genotypes was associated with the rate of decline of lung function. However, the distribution of IL1B/IL1RN haplotypes was different between smokers with a rapid decline in lung function and those with no decline in lung function (p=0.0005).
conclusionThese results suggest that IL1B/IL1RN haplotypes play a role in the rate of decline in lung function in smokers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.