ReviewOncogene2001
The NOD: a signaling module that regulates apoptosis and host defense against pathogens.
Review in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
86 citing papers in PubMed, 1 synthesis or guideline pooled it, 233 citations in OpenAlex.
- Differential effects of NOD2 polymorphisms on colorectal cancer risk: a meta-analysis.International journal of colorectal disease · 2010Pooled it
- Trial
- An Integrated Analysis to Understand the Dysregulation of Innate Immune Response in Mouse Models of MASLD.Cells · 2026Article
- Structural and dynamic basis of NOD2 tandem CARD association and NOD1/2-RIP2 signaling complexes.PLoS computational biology · 2026Article
- The Role ofInternational journal of molecular sciences · 2025Review
- Editorial: Basic, clinical, and translational studies of Yao syndrome and other NOD2 related diseases.Frontiers in immunology · 2024Article
- NLRP3 inflammasome in atherosclerosis: Mechanisms and targeted therapies.Frontiers in pharmacology · 2024Review
- The NLR gene family: from discovery to present day.Nature reviews. Immunology · 2023Review
- An activated form of NB-ARC protein RLS1 functions with cysteine-rich receptor-like protein RMC to trigger cell death in rice.Plant communications · 2023Article
- Immunity in Sea Turtles: Review of a Host-Pathogen Arms Race Millions of Years in the Running.Animals : an open access journal from MDPI · 2023Review
- NLRP3 inflammasome activation mechanism and its role in autoimmune liver disease.Acta biochimica et biophysica Sinica · 2022Review
- Surgical Strikes on Host Defenses: Role of the Viral Protease Activity in Innate Immune Antagonism.Pathogens (Basel, Switzerland) · 2022Review
- Beyond the Trauma Triad of Death-New Advances in Our Knowledge of Pathophysiology as a Basis for New Perspectives in Support Therapy.Life (Basel, Switzerland) · 2022Article
- Muramyl dipeptide-based analogs as potential anticancer compounds: Strategies to improve selectivity, biocompatibility, and efficiency.Frontiers in oncology · 2022Review
- Role of nucleic acid sensing in the pathogenesis of type 1 diabetes.World journal of diabetes · 2021Review
- Laparoscopy in Emergency: Why Not? Advantages of Laparoscopy in Major Emergency: A Review.Life (Basel, Switzerland) · 2021Review
- Article
- Structure, Activation and Regulation of NLRP3 and AIM2 Inflammasomes.International journal of molecular sciences · 2021Review
- Innate and adaptive immune responses against coronavirus.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020Review
- Role of inflammatory markers in corona virus disease (COVID-19) patients: A review.Experimental biology and medicine (Maywood, N.J.) · 2020Review
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Nods, a growing family of proteins containing a nucleotide-binding oligomerization domain (NOD), are involved in the regulation of programmed cell death (PCD) and immune responses. Members of the family include Apaf-1, Ced-4, Nod1, Nod2, and the cytosolic products of plant disease resistance genes. The NOD module is homologous to the ATP-binding cassette (ABC) found in a large number of proteins with diverse biological function. The centrally located NOD promotes activation of effector molecules through self-association and induced proximity of binding partners. The C-terminal domain of Nods serves as a sensor for intracellular ligands, whereas the N-terminal domain mediates binding to dowstream effector molecules and activation of diverse signaling pathways. Thus, Nods activate, through the NOD module, diverse signaling pathways involved in the elimination of cells via PCD and the host defense against pathogens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.