ArticleJournal of neurology, neurosurgery, and psychiatry2001
Primary lateral sclerosis: clinical, neurophysiological, and magnetic resonance findings.
Article in Journal of neurology, neurosurgery, and psychiatry, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 116 citations in OpenAlex.
- Primary Lateral Sclerosis: An Overview.Journal of clinical medicine · 2024Review
- Altered Metabolism in Motor Neuron Diseases: Mechanism and Potential Therapeutic Target.Cells · 2023Review
- Editorial Comment: Iron-sensitive MR imaging of the primary motor cortex to differentiate hereditary spastic paraplegia from other motor neuron diseases.European radiology · 2022Article
- Cortical Excitability across the ALS Clinical Motor Phenotypes.Brain sciences · 2021Review
- Upper Motor Neuron Disorders: Primary Lateral Sclerosis, Upper Motor Neuron Dominant Amyotrophic Lateral Sclerosis, and Hereditary Spastic Paraplegia.Brain sciences · 2021Review
- Primary lateral sclerosis: consensus diagnostic criteria.Journal of neurology, neurosurgery, and psychiatry · 2020Article
- Glial Cells-The Strategic Targets in Amyotrophic Lateral Sclerosis Treatment.Journal of clinical medicine · 2020Review
- Pathological Crying and Laughing in Motor Neuron Disease: Pathobiology, Screening, Intervention.Frontiers in neurology · 2019Review
- Primary lateral sclerosis and the amyotrophic lateral sclerosis-frontotemporal dementia spectrum.Journal of neurology · 2018Article
- Amyotrophic Lateral Sclerosis and its Mimics/Variants: A Comprehensive Review.Journal of clinical imaging science · 2018Review
- Altered cortical beta-band oscillations reflect motor system degeneration in amyotrophic lateral sclerosis.Human brain mapping · 2017Article
- Primary Lateral Sclerosis.Neurologic clinics · 2015Review
- Eye-tracking in amyotrophic lateral sclerosis: A longitudinal study of saccadic and cognitive tasks.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2015Article
- Intrahemispheric and interhemispheric structural network abnormalities in PLS and ALS.Human brain mapping · 2014Article
- Clinical and imaging characterization of progressive spastic dysarthria.European journal of neurology · 2014Article
- Myelin imaging in amyotrophic and primary lateral sclerosis.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2013Article
- Extramotor damage is associated with cognition in primary lateral sclerosis patients.PloS one · 2013Article
- High T2 signal in primary lateral sclerosis supports the topographic distribution of fibers in the corpus callosum: assessing disease in the primary motor segment.AJNR. American journal of neuroradiology · 2011Article
- Cortical processing of swallowing in ALS patients with progressive dysphagia--a magnetoencephalographic study.PloS one · 2011Article
- Voxel-based diffusion tensor imaging detects pyramidal tract degeneration in primary lateral sclerosis.The British journal of radiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo describe the clinical, neurophysiological, and MRI findings in 10 patients with primary lateral sclerosis (PLS).
resultsThe course of the disease was very slowly progressive. Spasticity due to upper motor neuron dysfunction was the most prominent sign, but EMG showed slight lower motor neuron signs, such as a mixed pattern on maximal voluntary contraction and enlarged motor unit potentials. One patient had clinically mild lower motor neuron involvement. Central motor conduction times (CMCT) were more prolonged in PLS than is the case in ALS. Minor sensory signs were found on neurophysiological examination, comparable with those in ALS. In four patients serum creatine kinase activity was raised. On MRI cortical atrophy was seen, most pronounced in the precentral gyrus and expanding into the parietal-occipital region.
conclusionsPLS is a distinct clinical syndrome, part of the range of motor neuron diseases. Besides pronounced upper motor neuron symptoms, mild lower motor neuron symptoms can also be found, as well as (subclinical) sensory symptoms. PLS can be distinguished from ALS by its slow clinical course, a severely prolonged MEP, and a more extensive focal cortical atrophy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.