ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
A dopamine- and protein kinase A-dependent mechanism for network adaptation in retinal ganglion cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 63 citations in OpenAlex.
- Dopaminergic amacrine cells express HCN channels in the developing and adult mouse retina.bioRxiv : the preprint server for biology · 2024Article
- Retinal Alterations Predict Early Prodromal Signs of Neurodegenerative Disease.International journal of molecular sciences · 2024Review
- Circadian clock organization in the retina: From clock components to rod and cone pathways and visual function.Progress in retinal and eye research · 2023Review
- Dopamine D1 and D4 receptors contribute to light adaptation in ON-sustained retinal ganglion cells.Journal of neurophysiology · 2021Article
- Increased Retinal Ganglion Cell Survival by Exogenous IL-2 Depends on IL-10, Dopamine D1 Receptors, and Classical IL-2/IL-2R Signaling Pathways.Neurochemical research · 2021Article
- Dopamine D2 Receptor-Mediated Modulation of Rat Retinal Ganglion Cell Excitability.Neuroscience bulletin · 2020Article
- Dopaminergic Modulation of Signal Processing in a Subset of Retinal Bipolar Cells.Frontiers in cellular neuroscience · 2020Article
- Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.Progress in retinal and eye research · 2019Review
- 'Central' Actions of Corticosteroid Signaling Suggested by Constitutive Knockout of Corticosteroid Receptors in Small Fish.Nutrients · 2019Review
- Expression of GluA2-containing calcium-impermeable AMPA receptors on dopaminergic amacrine cells in the mouse retina.Molecular vision · 2019Article
- Mechanisms creating transient and sustained photoresponses in mammalian retinal ganglion cells.The Journal of general physiology · 2017Article
- Dopamine D1 receptor expression is bipolar cell type-specific in the mouse retina.The Journal of comparative neurology · 2016Article
- Fixation strategies for retinal immunohistochemistry.Progress in retinal and eye research · 2015Review
- Dopamine D2 receptors preferentially regulate the development of light responses of the inner retina.The European journal of neuroscience · 2015Article
- Adenosine modulates light responses of rat retinal ganglion cell photoreceptors througha cAMP-mediated pathway.The Journal of physiology · 2014Article
- Effects of dopamine receptor blockade on the intensity-response function of electroretinographic b- and d-waves in light-adapted eyes.Journal of neural transmission (Vienna, Austria : 1996) · 2014Article
- Dopamine D1 receptors regulate the light dependent development of retinal synaptic responses.PloS one · 2013Article
- Glucocorticoid receptor activity regulates light adaptation in the zebrafish retina.Frontiers in neural circuits · 2013Article
- Dopamine and full-field illumination activate D1 and D2-D5-type receptors in adult rat retinal ganglion cells.The Journal of comparative neurology · 2012Article
- Dopaminergic modulation of ganglion-cell photoreceptors in rat.The European journal of neuroscience · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Vertebrates can detect light intensity changes in vastly different photic environments, in part, because postreceptoral neurons undergo "network adaptation." Previous data implicated dopaminergic, cAMP-dependent inhibition of retinal ganglion cells in this process yet left unclear how this occurs and whether this occurs in darkness versus light. To test for light- and dopamine-dependent changes in ganglion cell cAMP levels in situ, we immunostained dark- and light-adapted retinas with anti-cAMP antisera in the presence and absence of various dopamine receptor ligands. To test for direct effects of dopamine receptor ligands and membrane-permeable protein kinase ligands on ganglion cell excitability, we recorded spikes from isolated ganglion cells in perforated-patch whole-cell mode before and during application of these agents by microperfusion. Our immunostainings show that light, endogenous dopamine, and exogenous dopamine elevate ganglion cell cAMP levels in situ by activating D1-type dopamine receptors. Our spike recordings show that D1-type agonists and 8-bromo cAMP reduce spike frequency and curtail sustained spike firing and that these effects entail protein kinase A activation. These effects resemble those of background light on ganglion cell responses to light flashes. Network adaptation could thus be produced, to some extent, by dopaminergic modulation of ganglion cell spike generation, a mechanism distinct from modulation of transmitter release onto ganglion cells or of transmitter-gated currents in ganglion cells. Combining these observations with results obtained in studies of photoreceptor, bipolar, and horizontal cells indicates that all three layers of neurons in the retina are equipped with mechanisms for adaptation to ambient light intensity.
Indexed as
Identifiers
11606650PMC3245881W1676323133What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.