ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Neurotrophin-4 deficient mice have a loss of vagal intraganglionic mechanoreceptors from the small intestine and a disruption of short-term satiety.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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Who cites it
36 citing papers in PubMed.
- Gut-brain communication: types of sensory nerves and mechanisms of activation.Nature reviews. Gastroenterology & hepatology · 2026Review
- RYGB induces vagal sensory neuropathy characterized by altered Glp1r expression and enhanced exendin-4 responsiveness in male mice.American journal of physiology. Endocrinology and metabolism · 2026Article
- Analysis of the spinal and vagal afferent innervation of the mouse colon using neuronal retrograde tracers.Cell and tissue research · 2023Article
- Neural signalling of gut mechanosensation in ingestive and digestive processes.Nature reviews. Neuroscience · 2022Review
- Intact vagal gut-brain signalling prevents hyperphagia and excessive weight gain in response to high-fat high-sugar diet.Acta physiologica (Oxford, England) · 2021Article
- Gut-to-brain signals in feeding control.American journal of physiology. Endocrinology and metabolism · 2021Review
- Optogenetic Manipulation of the Vagus Nerve.Advances in experimental medicine and biology · 2021Article
- Article
- Dissecting the Role of Subtypes of Gastrointestinal Vagal Afferents.Frontiers in physiology · 2020Review
- The metabolic role of vagal afferent innervation.Nature reviews. Gastroenterology & hepatology · 2018Review
- Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms.Molecular metabolism · 2018Article
- Subdiaphragmatic Vagotomy With Pyloroplasty Ameliorates the Obesity Caused by Genetic Deletion of the Melanocortin 4 Receptor in the Mouse.Frontiers in neuroscience · 2018Article
- You Are What You (First) Eat.Frontiers in human neuroscience · 2018Review
- NaMolecular metabolism · 2017Review
- Article
- Article
- The role of gastrointestinal vagal afferent fibres in obesity.The Journal of physiology · 2015Review
- Reduced intestinal brain-derived neurotrophic factor increases vagal sensory innervation of the intestine and enhances satiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Loss of neurotrophin-3 from smooth muscle disrupts vagal gastrointestinal afferent signaling and satiation.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Vagal afferent controls of feeding: a possible role for gastrointestinal BDNF.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2013Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Intraganglionic laminar endings (IGLEs) and intramuscular arrays (IMAs) are the two putative mechanoreceptors that the vagus nerve supplies to gastrointestinal smooth muscle. To examine whether neurotrophin-4 (NT-4)-deficient mice, which have only 45% of the normal number of nodose ganglion neurons, exhibit selective losses of these endings and potentially provide a model for assessing their functional roles, we inventoried IGLEs and IMAs in the gut wall. Vagal afferents were labeled by nodose ganglion injections of wheat germ agglutinin-horseradish peroxidase, and a standardized sampling protocol was used to map the terminals in the stomach, duodenum, and ileum. NT-4 mutants had a substantial organ-specific reduction of IGLEs; whereas the morphologies and densities of both IGLEs and IMAs in the stomach were similar to wild-type patterns, IGLEs were largely absent in the small intestine (90 and 81% losses in duodenum and ileum, respectively). Meal pattern analyses revealed that NT-4 mutants had increased meal durations with solid food and increased meal sizes with liquid food. However, daily total food intake and body weight remained normal because of compensatory changes in other meal parameters. These findings indicate that NT-4 knock-out mice have a selective vagal afferent loss and suggest that intestinal IGLEs (1) may participate in short-term satiety, probably by conveying feedback about intestinal distension or transit to the brain, (2) are not essential for long-term control of feeding and body weight, and (3) play different roles in regulation of solid and liquid diet intake.
Indexed as
Identifiers
11606648PMC6762821What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.