ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Potentiation of L-type calcium channels reveals nonsynaptic mechanisms that correlate spontaneous activity in the developing mammalian retina.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 66 citations in OpenAlex.
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- On the Diverse Functions of Electrical Synapses.Frontiers in cellular neuroscience · 2022Review
- Building a circuit through correlated spontaneous neuronal activity in the developing vertebrate and invertebrate visual systems.Genes & development · 2021Review
- The Efemp1R345W Macular Dystrophy Mutation Causes Amplified Circadian and Photophobic Responses to Light in Mice.Investigative ophthalmology & visual science · 2019Article
- Retinal Waves Modulate an Intraretinal Circuit of Intrinsically Photosensitive Retinal Ganglion Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Elucidating the role of AII amacrine cells in glutamatergic retinal waves.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- GABAA receptor-mediated tonic depolarization in developing neural circuits.Molecular neurobiology · 2014Review
- Adenosine A(2A) receptor up-regulates retinal wave frequency via starburst amacrine cells in the developing rat retina.PloS one · 2014Article
- Correlated spontaneous activity persists in adult retina and is suppressed by inhibitory inputs.PloS one · 2013Article
- Intercellular calcium signaling in a gap junction-coupled cell network establishes asymmetric neuronal fates in C. elegans.Development (Cambridge, England) · 2012Article
- Electrical activity as a developmental regulator in the formation of spinal cord circuits.Current opinion in neurobiology · 2012Review
- Cellular mechanisms underlying spatiotemporal features of cholinergic retinal waves.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Network deficiency exacerbates impairment in a mouse model of retinal degeneration.Frontiers in systems neuroscience · 2012Article
- Assembly and disassembly of a retinal cholinergic network.Visual neuroscience · 2012Review
- Synaptotagmin I regulates patterned spontaneous activity in the developing rat retina via calcium binding to the C2AB domains.PloS one · 2012Article
- The role of neuronal connexins 36 and 45 in shaping spontaneous firing patterns in the developing retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Requirements for synaptically evoked plateau potentials in relay cells of the dorsal lateral geniculate nucleus of the mouse.The Journal of physiology · 2011Article
- Mechanisms underlying spontaneous patterned activity in developing neural circuits.Nature reviews. Neuroscience · 2010Review
- Spatial-temporal patterns of retinal waves underlying activity-dependent refinement of retinofugal projections.Neuron · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although correlated neural activity is a hallmark of many regions of the developing nervous system, the neural events underlying its propagation remain largely unknown. In the developing vertebrate retina, waves of spontaneous, correlated neural activity sweep across the ganglion cell layer. Here, we demonstrate that L-type Ca(2+) channel agonists induce large, frequent, rapidly propagating waves of neural activity in the developing retina. In contrast to retinal waves that have been described previously, these L-type Ca(2+) channel agonist-potentiated waves propagate independent of fast synaptic transmission. Bath application of nicotinic acetylcholine, AMPA, NMDA, glycine, and GABA(A) receptor antagonists does not alter the velocity, frequency, or size of the potentiated waves. Additionally, these antagonists do not alter the frequency or magnitude of spontaneous depolarizations that are recorded in individual retinal ganglion cells. Like normal retinal waves, however, the area over which the potentiated waves propagate is reduced dramatically by 18alpha-glycyrrhetinic acid, a blocker of gap junctions. Additionally, like normal retinal waves, L-type Ca(2+) channel agonist-potentiated waves are abolished by adenosine deaminase, which degrades extracellular adenosine, and by aminophylline, a general adenosine receptor antagonist, indicating that they are dependent on adenosine-mediated signaling. Our study indicates that although the precise spatiotemporal properties of retinal waves are shaped by local synaptic inputs, activity may be propagated through the developing mammalian retina by nonsynaptic pathways.
Indexed as
Identifiers
11606640PMC6762803W2126657192What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.