ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Paired-pulse plasticity at the single release site level: an experimental and computational study.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
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- The development of functional glutamatergic and GABAergic synaptic connections between vestibulo-ocular projection neurons and oculomotor motoneurons in the chicken embryo.Frontiers in neurology · 2025Article
- The Lack of Synapsin Alters Presynaptic Plasticity at Hippocampal Mossy Fibers in Male Mice.eNeuro · 2024Article
- Exact Distribution of the Quantal Content in Synaptic Transmission.Physical review letters · 2024Article
- Article
- Studying Synaptic Connectivity and Strength with Optogenetics and Patch-Clamp Electrophysiology.International journal of molecular sciences · 2022Review
- Upregulated CaCells · 2022Article
- Glia as sculptors of synaptic plasticity.Neuroscience research · 2021Review
- Presynaptic endoplasmic reticulum regulates short-term plasticity in hippocampal synapses.Communications biology · 2021Article
- Noisy Synaptic Conductance: Bug or a Feature?Trends in neurosciences · 2020Review
- Tonic GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- CXCR7 regulates epileptic seizures by controlling the synaptic activity of hippocampal granule cells.Cell death & disease · 2019Article
- Synaptic plasticity in hippocampal CA1 neurons and learning behavior in acute kidney injury, and estradiol replacement in ovariectomized rats.BMC neuroscience · 2019Article
- The Small and Dynamic Pre-primed Pool at the Release Site; A Useful Concept to Understand Release Probability and Short-Term Synaptic Plasticity?Frontiers in synaptic neuroscience · 2019Review
- Loss of estrogen-related receptor alpha disrupts ventral-striatal synaptic function in female mice.Neuroscience · 2016Article
- Facilitated glutamate release at Schaffer collateral to CA1 synapses has access to an exclusive population of NMDA receptors.Brain research · 2015Article
- Prion protein facilitates synaptic vesicle release by enhancing release probability.Human molecular genetics · 2014Article
- Article
- Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CA3-CA1 glutamatergic synapses in the hippocampus exhibit a large heterogeneity in release probability (p) and paired-pulse (PP) plasticity, established already in the early neonatal period when the CA3-CA1 connections consist of only a single release site. At such a site two factors decide initial release probability: the number of immediately releasable vesicles (preprimed pool) and the vesicle release probability (P(ves1)). Depletion and replenishment of this pool, an alteration in P(ves), and desensitization of postsynaptic receptors may contribute to PP plasticity. A model based on data from single neonatal CA3-CA1 synapses has been used to address the relative importance of these factors for the heterogeneity in PP plasticity. At a 20 msec PP interval, the PP ratio (P(2)/P(1)) varied from 0.1 to 4.5 among the synapses. At this interval desensitization and replenishment were of little importance. The heterogeneity was explained mostly by the variation in P(ves1), whereas the preprimed pool size was of minor importance. P(ves) altered from the first to the second stimulus such that P(ves2) was rather uniform among the synapses. Its variation thus contributed little to the heterogeneity in PP ratio. The model also shows that the relationship between alterations in release probability and PP ratio is complex. Thus, an increase in release probability can be associated with an increase, a decrease, or no change at all in PP ratio, depending on the original values of P(ves1) and the preprimed pool and on which one of these factors is altered to produce the increase in release probability.
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11606624PMC6762810What OpenQuestion holds
Registered trials
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