ArticleGenetics2001
Dynamics of microsatellite divergence under stepwise mutation and proportional slippage/point mutation models.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Inherent instability of simple DNA repeats shapes an evolutionarily stable distribution of repeat lengths.Nature communications · 2025Article
- Ancient and Modern Genomes Reveal Microsatellites Maintain a Dynamic Equilibrium Through Deep Time.Genome biology and evolution · 2024Article
- Origin and dispersion pathways of guava in the Galapagos Islands inferred through genetics and historical records.Ecology and evolution · 2021Article
- Recent genetic connectivity and clinal variation in chimpanzees.Communications biology · 2021Article
- Distribution patterns and variation analysis of simple sequence repeats in different genomic regions of bovid genomes.Scientific reports · 2018Article
- Challenges in analysis and interpretation of microsatellite data for population genetic studies.Ecology and evolution · 2014Review
- Microsatellites as targets of natural selection.Molecular biology and evolution · 2013Article
- Microevolution of pandemic Vibrio parahaemolyticus assessed by the number of repeat units in short sequence tandem repeat regions.PloS one · 2012Article
- Article
- Measuring microsatellite conservation in mammalian evolution with a phylogenetic birth-death model.Genome biology and evolution · 2012Article
- Empirical evaluation reveals best fit of a logistic mutation model for human Y-chromosomal microsatellites.Genetics · 2011Article
- Genetic diversity of microsatellite loci in hierarchically structured populations.Theoretical population biology · 2011Article
- Joint inference of microsatellite mutation models, population history and genealogies using transdimensional Markov Chain Monte Carlo.Genetics · 2011Article
- Article
- Phylogeography, genetic structure and population divergence time of cheetahs in Africa and Asia: evidence for long-term geographic isolates.Molecular ecology · 2011Article
- Mutation biases and mutation rate variation around very short human microsatellites revealed by human-chimpanzee-orangutan genomic sequence alignments.Journal of molecular evolution · 2010Article
- Mutational dynamics of microsatellites.Molecular biotechnology · 2010Review
- Rapid evolution of simple sequence repeat induced by allopolyploidization.Journal of molecular evolution · 2009Article
- Genome-wide analysis of conservation and divergence of microsatellites in rice.Molecular genetics and genomics : MGG · 2009Article
- Comparative genomics and molecular dynamics of DNA repeats in eukaryotes.Microbiology and molecular biology reviews : MMBR · 2008Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Recently Kruglyak, Durrett, Schug, and Aquadro showed that microsatellite equilibrium distributions can result from a balance between polymerase slippage and point mutations. Here, we introduce an elaboration of their model that keeps track of all parts of a perfect repeat and a simplification that ignores point mutations. We develop a detailed mathematical theory for these models that exhibits properties of microsatellite distributions, such as positive skewness of allele lengths, that are consistent with data but are inconsistent with the predictions of the stepwise mutation model. We use our theoretical results to analyze the successes and failures of the genetic distances (delta(mu))(2) and D(SW) when used to date four divergences: African vs. non-African human populations, humans vs. chimpanzees, Drosophila melanogaster vs. D. simulans, and sheep vs. cattle. The influence of point mutations explains some of the problems with the last two examples, as does the fact that these genetic distances have large stochastic variance. However, we find that these two features are not enough to explain the problems of dating the human-chimpanzee split. One possible explanation of this phenomenon is that long microsatellites have a mutational bias that favors contractions over expansions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.