ArticleGenetics2001
Patterns of DNA sequence variation suggest the recent action of positive selection in the janus-ocnus region of Drosophila simulans.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Predicting the Landscape of Recombination Using Deep Learning.Molecular biology and evolution · 2020Article
- A Large Panel of Drosophila simulans Reveals an Abundance of Common Variants.Genome biology and evolution · 2018Article
- Molecular diversity, population structure, and linkage disequilibrium in a worldwide collection of tobacco (Nicotiana tabacum L.) germplasm.BMC genetics · 2012Article
- Identification of selection signatures in cattle breeds selected for dairy production.Genetics · 2010Article
- On the utility of linkage disequilibrium as a statistic for identifying targets of positive selection in nonequilibrium populations.Genetics · 2007Article
- Nucleotide variation at the dopa decarboxylase (Ddc) gene in natural populations of Drosophila melanogaster.Journal of genetics · 2007Article
- Population structure and its effects on patterns of nucleotide polymorphism in teosinte (Zea mays ssp. parviglumis).Genetics · 2007Article
- Unusual pattern of nucleotide sequence variation at the OS-E and OS-F genomic regions of Drosophila simulans.Genetics · 2007Article
- Molecular population genetics of accessory gland protein genes and testis-expressed genes in Drosophila mojavensis and D. arizonae.Genetics · 2005Article
- Genomic scans for selective sweeps using SNP data.Genome research · 2005Article
- Patterns of synonymous codon usage in Drosophila melanogaster genes with sex-biased expression.Genetics · 2005Article
- The population genetics of the alpha-2 globin locus of orangutans (Pongo pygmaeus).Journal of molecular evolution · 2005Article
- Article
- Linkage disequilibrium as a signature of selective sweeps.Genetics · 2004Article
- Molecular population genetics of male accessory gland proteins in the Drosophila simulans complex.Genetics · 2004Article
- Functional divergence in tandemly duplicated Arabidopsis thaliana trypsin inhibitor genes.Genetics · 2004Article
- Selective constraints on intron evolution in Drosophila.Genetics · 2003Article
- Article
- The signature of positive selection at randomly chosen loci.Genetics · 2002Article
Corrections and comments
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Authors and funding
3 authors.
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Abstract
Levels of nucleotide polymorphism in three paralogous Drosophila simulans genes, janusA (janA), janusB (janB), and ocnus (ocn), were surveyed by DNA sequencing. The three genes lie in tandem within a 2.5-kb region of chromosome arm 3R. In a sample of eight alleles from a worldwide distribution we found a significant departure from neutrality by several statistical tests. The most striking feature of this sample was that in a 1.7-kb region containing the janA and janB genes, 30 out of 31 segregating sites contained variants present only once in the sample, and 29 of these unique variants were found in the same allele. A restriction survey of an additional 28 lines of D. simulans revealed strong linkage disequilibrium over the janA-janB region and identified six more alleles matching the rare haplotype. Among the rare alleles, the level of DNA sequence variation was typical for D. simulans autosomal genes and showed no departure from neutrality. In addition, the rare haplotype was more similar to the D. melanogaster sequence, indicating that it was the ancestral form. These results suggest that the derived haplotype has risen to high worldwide frequency relatively recently, most likely as a result of natural selection.
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