ArticleGenetics2001
Molecular population genetics and evolution of a prion-like protein in Saccharomyces cerevisiae.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 59 citations in OpenAlex.
- Prion-Dependent Lethality ofInternational journal of molecular sciences · 2025Article
- Anti-Prion Systems in Saccharomyces cerevisiae.Journal of neurochemistry · 2025Review
- Osmotic stress induces formation of both liquid condensates and amyloids by a yeast prion domain.The Journal of biological chemistry · 2024Article
- Review
- The Ecology and Evolution of the Baker's YeastGenes · 2022Review
- More than Just a Phase: Prions at the Crossroads of Epigenetic Inheritance and Evolutionary Change.Journal of molecular biology · 2018Review
- Sequence features governing aggregation or degradation of prion-like proteins.PLoS genetics · 2018Article
- Article
- Extracellular environment modulates the formation and propagation of particular amyloid structures.Molecular microbiology · 2014Article
- Amyloid diseases of yeast: prions are proteins acting as genes.Essays in biochemistry · 2014Article
- When amyloids become prions.Prion · 2014Article
- Prions in yeast.Genetics · 2012Review
- A computational pipeline to discover highly phylogenetically informative genes in sequenced genomes: application to Saccharomyces cerevisiae natural strains.Nucleic acids research · 2012Article
- [PSI+] Prion transmission barriers protect Saccharomyces cerevisiae from infection: intraspecies 'species barriers'.Genetics · 2012Article
- Insight into molecular basis of curing of [PSI+] prion by overexpression of 104-kDa heat shock protein (Hsp104).The Journal of biological chemistry · 2012Article
- Genetic and epigenetic control of the efficiency and fidelity of cross-species prion transmission.Molecular microbiology · 2010Article
- The evolutionary consequences of erroneous protein synthesis.Nature reviews. Genetics · 2009Review
- Prion switching in response to environmental stress.PLoS biology · 2008Article
- Amyloids: friend or foe?Journal of Alzheimer's disease : JAD · 2008Review
- Population genomics of the wild yeast Saccharomyces paradoxus: Quantifying the life cycle.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The prion-like behavior of Sup35p, the eRF3 homolog in the yeast Saccharomyces cerevisiae, mediates the activity of the cytoplasmic nonsense suppressor known as [PSI(+)]. Sup35p is divided into three regions of distinct function. The N-terminal and middle (M) regions are required for the induction and propagation of [PSI(+)] but are not necessary for translation termination or cell viability. The C-terminal region encompasses the termination function. The existence of the N-terminal region in SUP35 homologs of other fungi has led some to suggest that this region has an adaptive function separate from translation termination. To examine this hypothesis, we sequenced portions of SUP35 in 21 strains of S. cerevisiae, including 13 clinical isolates. We analyzed nucleotide polymorphism within this species and compared it to sequence divergence from a sister species, S. paradoxus. The N domain of Sup35p is highly conserved in amino acid sequence and is highly biased in codon usage toward preferred codons. Amino acid changes are under weak purifying selection based on a quantitative analysis of polymorphism and divergence. We also conclude that the clinical strains of S. cerevisiae are not recently derived and that outcrossing between strains in S. cerevisiae may be relatively rare in nature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.