ArticleBritish journal of pharmacology2001
Thrombin-induced platelet endostatin release is blocked by a proteinase activated receptor-4 (PAR4) antagonist.
Article in British journal of pharmacology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- PAR1-mediated Non-periodical Synchronized Calcium Oscillations in Human Mesangial Cells.Function (Oxford, England) · 2024Article
- Activation of Human Platelets byPathogens (Basel, Switzerland) · 2022Article
- Protease Activated Receptor 1 and Its Ligands as Main Regulators of the Regeneration of Peripheral Nerves.Biomolecules · 2021Review
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- Platelets and Platelet-Derived Extracellular Vesicles in Liver Physiology and Disease.Hepatology communications · 2019Review
- Article
- Biased signaling of protease-activated receptors.Frontiers in endocrinology · 2014Review
- The role of platelets in tumour growth.Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti · 2012Review
- Protease-activated receptors in cancer: A systematic review.Oncology letters · 2011Article
- What role for angiogenesis in childhood acute lymphoblastic leukaemia?Advances in hematology · 2011Article
- Platelet proteome and tumor dormancy: can platelets content serve as predictive biomarkers for exit of tumors from dormancy?Cancers · 2010Article
- Quiescent platelets stimulate angiogenesis and diabetic wound repair.The Journal of surgical research · 2010Article
- Article
- Tumors stimulate platelet delivery of angiogenic factors in vivo: an unexpected benefit.The American journal of pathology · 2008Article
- Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers.The Journal of experimental medicine · 2007Article
- Platelets accelerate gastric ulcer healing through presentation of vascular endothelial growth factor.British journal of pharmacology · 2006Article
- Roles of platelets and proteinase-activated receptors in gastric ulcer healing.Digestive diseases and sciences · 2005Review
- Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endostatin is a potent endogenous inhibitor of angiogenesis that was recently shown to be stored in platelets and released in response to thrombin, but not ADP. In the present study, we have tested the hypothesis that thrombin-induced endostatin release from rat platelets is mediated via proteinase-activated receptor-4 (PAR4). Immunoprecipitation and Western blotting confirmed that endostatin is contained within rat platelets. Aggregation and release of endostatin could be elicited by thrombin (0.5 - 1.0 U ml(-1)) or by specific PAR4 agonist (AYPGKF-NH(2); AY-NH(2); 15 - 50 microM). Significant release of endostatin could be induced by a dose of thrombin below that necessary for induction of aggregation. An adenosine diphosphate (ADP) scavenger, apyrase, inhibited the platelet aggregation induced by thrombin, but not the release of endostatin. In contrast, a selective PAR4 antagonist (trans-cinnamoyl-YPGKF-NH(2); tcY-NH(2)) prevented endostatin release and aggregation induced by thrombin or by AY-NH(2). We conclude that thrombin-induced endostatin release from rat platelets is PAR4-mediated via an ADP-independent mechanism that can occur independently of platelet aggregation.
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