ArticleBiophysical journal2001
Mapping the energy surface of transmembrane helix-helix interactions.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Phosphatidylinositol Interactions with the SARS-CoV-2 Envelope Protein Investigated by LipidBiochemistry · 2026Article
- Viroporins in the Influenza Virus.Cells · 2019Review
- Molecular dynamics simulations of homo-oligomeric bundles embedded within a lipid bilayer.Biophysical journal · 2013Article
- Effect of cysteine mutations in the extracellular domain of CM2 on the influenza C virus replication.PloS one · 2013Article
- ORF8a of SARS-CoV forms an ion channel: experiments and molecular dynamics simulations.Biochimica et biophysica acta · 2011Article
- Coarse-grained molecular dynamics of tetrameric transmembrane peptide bundles within a lipid bilayer.Chemistry and physics of lipids · 2010Article
- Structure and ion channel activity of the human respiratory syncytial virus (hRSV) small hydrophobic protein transmembrane domain.Protein science : a publication of the Protein Society · 2008Article
- Amantadine-induced conformational and dynamical changes of the influenza M2 transmembrane proton channel.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Molecular dynamics simulation approach for the prediction of transmembrane helix-helix heterodimers assembly.European biophysics journal : EBJ · 2007Article
- Lipid bilayer perturbations around a transmembrane nanotube: a coarse grain molecular dynamics study.Biophysical journal · 2005Article
- The transmembrane oligomers of coronavirus protein E.Biophysical journal · 2005Article
- Quantification of helix-helix binding affinities in micelles and lipid bilayers.Protein science : a publication of the Protein Society · 2004Article
- A structural model of EmrE, a multi-drug transporter from Escherichia coli.Biophysical journal · 2004Article
- Contribution of energy values to the analysis of global searching molecular dynamics simulations of transmembrane helical bundles.Biophysical journal · 2002Article
- Expression, purification, and activities of full-length and truncated versions of the integral membrane protein Vpu from HIV-1.Protein science : a publication of the Protein Society · 2002Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transmembrane helices are no longer believed to be just hydrophobic segments that exist solely to anchor proteins to a lipid bilayer, but rather they appear to have the capacity to specify function and structure. Specific interactions take place between hydrophobic segments within the lipid bilayer whereby subtle mutations that normally would be considered innocuous can result in dramatic structural differences. That such specificity takes place within the lipid bilayer implies that it may be possible to identify the most favorable interaction surface of transmembrane alpha-helices based on computational methods alone, as shown in this study. Herein, an attempt is made to map the energy surface of several transmembrane helix-helix interactions for several homo-oligomerizing proteins, where experimental data regarding their structure exist (glycophorin A, phospholamban, Influenza virus A M2, Influenza virus C CM2, and HIV vpu). It is shown that due to symmetry constraints in homo-oligomers the computational problem can be simplified. The results obtained are mostly consistent with known structural data and may additionally provide a view of possible alternate and intermediate configurations.
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