ArticleBiophysical journal2001
The influence of plasma membrane electrostatic properties on the stability of cell ionic composition.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 35 citations in OpenAlex.
- Noninvasive glucose monitoring: increasing accuracy by combination of multi-technology and multi-sensors.Journal of diabetes science and technology · 2010Trial
- Noninvasive glucose monitoring: a novel approach.Journal of diabetes science and technology · 2009Trial
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- Discovery of Quinazolone Pyridiniums as Potential Broad-Spectrum Antibacterial Agents.Molecules (Basel, Switzerland) · 2025Article
- Emerging Diamond Quantum Sensing in Bio-Membranes.Membranes · 2022Review
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- Proximity-induced electrodeformation and membrane capacitance coupling between cells.European biophysics journal : EBJ · 2021Article
- Millimeter Wave Radiation Activates Leech Nociceptors via TRPV1-Like Receptor Sensitization.Biophysical journal · 2019Article
- Photodynamic therapy disinfection of carious tissue mediated by aluminum-chloride-phthalocyanine entrapped in cationic liposomes: an in vitro and clinical study.Lasers in medical science · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An electro-osmotic model is developed to examine the influence of plasma membrane superficial charges on the regulation of cell ionic composition. Assuming membrane osmotic equilibrium, the ion distribution predicted by Gouy-Chapman-Grahame (GCG) theory is introduced into ion transport equations, which include a kinetic model of the Na/K-ATPase based on the stimulation of this ion pump by internal Na(+) ions. The algebro-differential equation system describing dynamics of the cell model has a unique resting state, stable with respect to finite-sized perturbations of various types. Negative charges on the membrane are found to greatly enhance relaxation toward steady state following these perturbations. We show that this heightened stability stems from electrostatic interactions at the inner membrane side that shift resting state coordinates along the sigmoidal activation curve of the sodium pump, thereby increasing the pump sensitivity to internal Na(+) fluctuations. The accuracy of electrostatic potential description with GCG theory is proved using an alternate formalism, based on irreversible thermodynamics, which shows that pressure contribution to ion potential energy is negligible in electrostatic double layers formed at the surfaces of biological membranes. We discuss implications of the results regarding a reliable operation of ionic process coupled to the transmembrane electrochemical gradient of Na(+) ions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.