ArticleMolecular and cellular biology2001
The notch intracellular domain can function as a coactivator for LEF-1.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 119 citations in OpenAlex.
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- Role of Notch signaling pathway in joint homeostasis and osteoarthritis.Frontiers in bioengineering and biotechnology · 2026Review
- Article
- Structure and Functions of HMGB2 Protein.International journal of molecular sciences · 2023Review
- Molecular Mechanisms in Genetic Aortopathy-Signaling Pathways and Potential Interventions.International journal of molecular sciences · 2023Review
- Effects of different signaling pathways on odontogenic differentiation of dental pulp stem cells: a review.Frontiers in physiology · 2023Review
- Non-canonical Wnt signaling participates in Jagged1-induced osteo/odontogenic differentiation in human dental pulp stem cells.Scientific reports · 2022Article
- Notch Signaling in Skeletal Development, Homeostasis and Pathogenesis.Biomolecules · 2020Review
- Pinning Down the Transcription: A Role for Peptidyl-ProlylFrontiers in cell and developmental biology · 2020Review
- Notch pathway: a bistable inducer of biological noise?Cell communication and signaling : CCS · 2019Review
- The Extracellular Matrix Receptor Discoidin Domain Receptor 1 Regulates Collagen Transcription by Translocating to the Nucleus.Journal of the American Society of Nephrology : JASN · 2019Article
- Wnt, Notch, and TGF-β Pathways Impinge on Hedgehog Signaling Complexity: An Open Window on Cancer.Frontiers in genetics · 2019Review
- Early mortality in acute promyelocytic leukemia: Potential predictors.Oncology letters · 2018Article
- LEF1 reduces tumor progression and induces myodifferentiation in a subset of rhabdomyosarcoma.Oncotarget · 2017Article
- Identification of critical paralog groups with indispensable roles in the regulation of signaling flow.Scientific reports · 2016Article
- Notch: A multi-functional integrating system of microenvironmental signals.Developmental biology · 2016Review
- Crosstalk between Nrf2 and Notch signaling.Free radical biology & medicine · 2015Review
- Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The molecular basis for load-induced skeletal muscle hypertrophy.Calcified tissue international · 2015Review
- F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner.The Journal of clinical investigation · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Notch signaling commences with two ligand-mediated proteolysis events that release the Notch intracellular domain, NICD, from the plasma membrane. NICD then translocates into the nucleus and interacts with the DNA binding protein CSL to activate transcription. We found that NICD expression also potentiates activity of the transcription factor LEF-1. NICD stimulation of LEF-1 activity was context dependent and occurred on a subset of promoters distinct from those activated by beta-catenin. Importantly, the effect of NICD does not appear to be mediated through canonical components of the Wnt signaling pathway or downstream components of the Notch pathway. In vitro assays show a weak association between the C-terminal transactivation domain of NICD and the high-mobility group domain of LEF-1, suggesting that the two proteins interact in vivo. Our data therefore describe a new nuclear target of Notch signaling and a new coactivator for LEF-1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.