ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2001
Reconstructing the eyes of Urbilateria.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 245 citations in OpenAlex.
- Allometry and Scaling of the Intraocular Pressure and Aqueous Humour Flow Rate in Vertebrate Eyes.PloS one · 2016Pooled it
- Extrinsic polarity cues control lamination versus cluster-based organization in vertebrate retinal development.iScience · 2026Article
- Comparative Analysis of Convergent Jellyfish Eyes Reveals Extensive Differences in Expression of Vision-Related Genes.Ecology and evolution · 2025Article
- Genomics Sheds New Light on the Ancestral Bilaterian Opsin Repertoire and Suggests Rhabdomeric Phototransduction in Xenacoelomorpha.Genome biology and evolution · 2025Article
- Single-cell sequencing suggests a conserved function of Hedgehog-signalling in spider eye development.EvoDevo · 2024Article
- Article
- Characterization of eyes, photoreceptors, and opsins in developmental stages of the arrow worm Spadella cephaloptera (Chaetognatha).Journal of experimental zoology. Part B, Molecular and developmental evolution · 2023Article
- Deep Diversity: Extensive Variation in the Components of Complex Visual Systems across Animals.Cells · 2022Review
- Article
- Phototransduction in a marine sponge provides insights into the origin of animal vision.iScience · 2022Article
- Evolutionary history limits species' ability to match colour sensitivity to available habitat light.Proceedings. Biological sciences · 2022Article
- Ultrastructure of cerebral eyes in Oweniidae and Chaetopteridae (Annelida) - implications for the evolution of eyes in Annelida.Zoological letters · 2022Article
- Ciliary photoreceptors in sea urchin larvae indicate pan-deuterostome cell type conservation.BMC biology · 2021Article
- Article
- CRISPR/CAS9 mutagenesis of a single r-opsin gene blocks phototaxis in a marine larva.Proceedings. Biological sciences · 2019Article
- Remnants of ancestral larval eyes in an eyeless mollusk? Molecular characterization of photoreceptors in the scaphopodEvoDevo · 2019Article
- Ciliary and rhabdomeric photoreceptor-cell circuits form a spectral depth gauge in marine zooplankton.eLife · 2018Article
- The nervous and visual systems of onychophorans and tardigrades: learning about arthropod evolution from their closest relatives.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Review
- Hierarchies in light sensing and dynamic interactions between ocular and extraocular sensory networks in a flatworm.Science advances · 2017Article
- The Last Common Ancestor of Most Bilaterian Animals Possessed at Least Nine Opsins.Genome biology and evolution · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The shared roles of Pax6 and Six homologues in the eye development of various bilaterians suggest that Urbilateria, the common ancestors of all Bilateria, already possessed some simple form of eyes. Here, we re-address the homology of bilaterian cerebral eyes at the level of eye anatomy, of eye-constituting cell types and of phototransductory molecules. The most widespread eye type found in Bilateria are the larval pigment-cup eyes located to the left and right of the apical organ in primary, ciliary larvae of Protostomia and Deuterostomia. They can be as simple as comprising a single pigment cell and a single photoreceptor cell in inverse orientation. Another more elaborate type of cerebral pigment-cup eyes with an everse arrangement of photoreceptor cells is found in adult Protostomia. Both inverse larval and everse adult eyes employ rhabdomeric photoreceptor cells and thus differ from the chordate cerebral eyes with ciliary photoreceptors. This is highly significant because on the molecular level we find that for phototransduction rhabdomeric versus ciliary photoreceptor cells employ divergent rhodopsins and non-orthologous G-proteins, rhodopsin kinases and arrestins. Our comparison supports homology of cerebral eyes in Protostomia; it challenges, however, homology of chordate and non-chordate cerebral eyes that employ photoreceptor cells with non-orthologous phototransductory cascades.
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