ArticleVirology2001
Further identification and characterization of novel intermediate and mature cleavage products released from the ORF 1b region of the avian coronavirus infectious bronchitis virus 1a/1b polyprotein.
Article in Virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
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- The cellular RNA helicase DDX1 interacts with coronavirus nonstructural protein 14 and enhances viral replication.Journal of virology · 2010Article
- Functional and genetic studies of the substrate specificity of coronavirus infectious bronchitis virus 3C-like proteinase.Journal of virology · 2010Article
- Inhibition of protein kinase R activation and upregulation of GADD34 expression play a synergistic role in facilitating coronavirus replication by maintaining de novo protein synthesis in virus-infected cells.Journal of virology · 2009Article
- Towards construction of viral vectors based on avian coronavirus infectious bronchitis virus for gene delivery and vaccine development.Journal of virological methods · 2009Article
- Complete genome sequence analysis of a predominant infectious bronchitis virus (IBV) strain in China.Virus genes · 2009Article
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- Construction of a severe acute respiratory syndrome coronavirus infectious cDNA clone and a replicon to study coronavirus RNA synthesis.Journal of virology · 2006Article
- The molecular biology of coronaviruses.Advances in virus research · 2006Review
- The coronavirus replicase.Current topics in microbiology and immunology · 2005Review
- Major genetic marker of nidoviruses encodes a replicative endoribonuclease.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Antigenicity analysis of different regions of the severe acute respiratory syndrome coronavirus nucleocapsid protein.Clinical chemistry · 2004Article
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Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The coronavirus 3C-like proteinase is one of the viral proteinases responsible for processing of the 1a and 1a/1b polyproteins to multiple mature products. In cells infected with avian coronavirus infectious bronchitis virus (IBV), three proteins of 100, 39, and 35 kDa, respectively, were previously identified as mature cleavage products released from the 1b region of the 1a/1b polyprotein by the 3C-like proteinase. In this report, we show the identification of two more cleavage products of 68 and 58 kDa released from the same region of the polyprotein. In addition, two stable intermediate cleavage products with molecular masses of 160 and 132 kDa, respectively, were identified in IBV-infected cells. The 160-kDa protein was shown to be an intermediate cleavage product covering the 100- and 68-kDa proteins, and the 132-kDa protein to be an intermediate cleavage product covering the 58-, 39-, and 35-kDa proteins. Immunofluorescent staining of IBV-infected cells and cells expressing individual cleavage products showed that the 100-, 68-, and 58-kDa proteins were associated with the membranes of the endoplasmic reticulum, and the 39- and 35-kDa proteins displayed diffuse distribution patterns.
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