ArticleNucleic acids research2001
Efficient repair of large DNA loops in Saccharomyces cerevisiae.
Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Responses of DNA Mismatch Repair Proteins to a Stable G-Quadruplex Embedded into a DNA Duplex Structure.International journal of molecular sciences · 2020Article
- The impact of poly-A microsatellite heterologies in meiotic recombination.Life science alliance · 2019Article
- Interconverting conformations of slipped-DNA junctions formed by trinucleotide repeats affect repair outcome.Biochemistry · 2013Article
- Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Partial reconstitution of DNA large loop repair with purified proteins from Saccharomyces cerevisiae.Nucleic acids research · 2008Article
- Oligonucleotide transformation of yeast reveals mismatch repair complexes to be differentially active on DNA replication strands.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- The large loop repair and mismatch repair pathways of Saccharomyces cerevisiae act on distinct substrates during meiosis.Genetics · 2005Article
- Instability of the insertional mutation in CftrTgH(neoim)Hgu cystic fibrosis mouse model.BMC genetics · 2004Article
- DNA polymerase delta, RFC and PCNA are required for repair synthesis of large looped heteroduplexes in Saccharomyces cerevisiae.Nucleic acids research · 2004Article
- Incorporation of large heterologies into heteroduplex DNA during double-strand-break repair in mouse cells.Genetics · 2002Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Small looped mispairs are efficiently corrected by mismatch repair. The situation with larger loops is less clear. Repair activity on large loops has been reported as anywhere from very low to quite efficient. There is also uncertainty about how many loop repair activities exist and whether any are conserved. To help address these issues, we studied large loop repair in Saccharomyces cerevisiae using in vivo and in vitro assays. Transformation of heteroduplexes containing 1, 16 or 38 nt loops led to >90% repair for all three substrates. Repair of the 38 base loop occurred independently of mutations in key genes for mismatch repair (MR) and nucleotide excision repair (NER), unlike other reported loop repair functions in yeast. Correction of the 16 base loop was mostly independent of MR, indicating that large loop repair predominates for this size heterology. Similarities between mammalian and yeast large loop repair were suggested by the inhibitory effects of loop secondary structure and by the role of defined nicks on the relative proportions of loop removal and loop retention products. These observations indicate a robust large loop repair pathway in yeast, distinct from MR and NER, and conserved in mammals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.