ArticleNucleic acids research2001
A novel class of plant-specific zinc-dependent DNA-binding protein that binds to A/T-rich DNA sequences.
Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 123 citations in OpenAlex.
- The Regulatory Army of Plant Defense: Transcription Factors in the War for Plant Immunity.International journal of molecular sciences · 2026Review
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- Effector FpECIR from Fusarium pseudograminearum targets wheat ethylene signaling pathway to suppress plant immunity.Stress biology · 2026Article
- Genome-wide identification of the CmPLATZ gene family and its role in cold acclimation and overwintering in Chrysanthemum morifolium.BMC plant biology · 2026Article
- Lily Transcription Factors LlPLATZ1 and LlMYB4 Orchestrate the Homeostasis of Heat Stress Responses via Antagonistic Regulation of LlHSF24.Plant biotechnology journal · 2026Article
- Genome-Wide Identification of the PLATZ Transcription Factor Family inPlants (Basel, Switzerland) · 2026Article
- Genome-wide characterisation and expression analysis ofFrontiers in plant science · 2026Article
- PLATZ transcription factors gene family in Brassica napus: genome-wide identification and expression analysis to abiotic stresses.BMC genomics · 2025Article
- Identification of the PLATZ gene family in Cucurbita pepo and functional analysis of CpPLATZ4 in powdery mildew stress response.Functional & integrative genomics · 2025Article
- Overexpression of cotton PLATZ transcription factors GhPLATZ01 and GhPLATZ15 improves the drought resistance of tomato.BMC plant biology · 2025Article
- Genome-Wide Identification and Salt Stress-Responsive Expression Analysis of thePlants (Basel, Switzerland) · 2025Article
- RcPLATZ8 as a novel negative regulator of flowering in Rosa chinensis.Plant cell reports · 2025Article
- The Overexpression ofInternational journal of molecular sciences · 2025Article
- Exploring the Roles of theInternational journal of molecular sciences · 2025Article
- Genome-Wide Study of Plant-Specific PLATZ Transcription Factors and Functional Analysis ofPlants (Basel, Switzerland) · 2025Article
- Plant AT-rich protein and zinc-binding protein (PLATZ) family in Dendrobium huoshanense: identification, evolution and expression analysis.BMC plant biology · 2024Article
- Genome-wide identification and salt stress expression analysis of the PLATZ transcription factor genes inBreeding science · 2024Article
- Comprehensive analysis of PLATZ family genes and their responses to abiotic stresses in Barley.BMC plant biology · 2024Article
- The Role of PLATZ6 in Raffinose Family Oligosaccharides Loading of Leaves via PLATZ Family Characterization in Cucumber.Plants (Basel, Switzerland) · 2024Article
- Functional Characterization of the Gibberellin (GA) Receptor ScGID1 in Sugarcane.International journal of molecular sciences · 2024Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complementary DNA encoding a DNA-binding protein, designated PLATZ1 (plant AT-rich sequence- and zinc-binding protein 1), was isolated from peas. The amino acid sequence of the protein is similar to those of other uncharacterized proteins predicted from the genome sequences of higher plants. However, no paralogous sequences have been found outside the plant kingdom. Multiple alignments among these paralogous proteins show that several cysteine and histidine residues are invariant, suggesting that these proteins are a novel class of zinc-dependent DNA-binding proteins with two distantly located regions, C-x(2)-H-x(11)-C-x(2)-C-x((4-5))-C-x(2)-C-x((3-7))-H-x(2)-H and C-x(2)-C-x((10-11))-C-x(3)-C. In an electrophoretic mobility shift assay, the zinc chelator 1,10-o-phenanthroline inhibited DNA binding, and two distant zinc-binding regions were required for DNA binding. A protein blot with (65)ZnCl(2) showed that both regions are required for zinc-binding activity. The PLATZ1 protein non-specifically binds to A/T-rich sequences, including the upstream region of the pea GTPase pra2 and plastocyanin petE genes. Expression of the PLATZ1 repressed those of the reporter constructs containing the coding sequence of luciferase gene driven by the cauliflower mosaic virus (CaMV) 35S90 promoter fused to the tandem repeat of the A/T-rich sequences. These results indicate that PLATZ1 is a novel class of plant-specific zinc-dependent DNA-binding protein responsible for A/T-rich sequence-mediated transcriptional repression.
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