Evidence map›Paper›PMID 11600695›Full record

Trial reportThe Journal of physiology2001

Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans.

P Hespel, B Op't Eijnde, M Van Leemputte, B Ursø, P L Greenhaff, V Labarque, S Dymarkowski, P Van Hecke, E A Richter

Open access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 9 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 9 syntheses or guidelines pooled it, 327 citations in OpenAlex.

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  20. Effect of thiol antioxidant on body fat and insulin reactivity.Journal of molecular medicine (Berlin, Germany) · 2004
    Trial

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

P HespelFaculty of Physical Education and Physiotherapy, Exercise Physiology and Biomechanics Laboratory, Department of Kinesiology, Faculty of Medicine, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
B Op't Eijnde
M Van Leemputte
B Ursø
P L Greenhaff
V Labarque
S Dymarkowski
P Van Hecke
E A Richter
KU Leuven · BEUniversity of Copenhagen · DKUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1. We investigated the effect of oral creatine supplementation during leg immobilization and rehabilitation on muscle volume and function, and on myogenic transcription factor expression in human subjects. 2. A double-blind trial was performed in young healthy volunteers (n = 22). A cast was used to immobilize the right leg for 2 weeks. Thereafter the subjects participated in a knee-extension rehabilitation programme (3 sessions x week(-1), 10 weeks). Half of the subjects received creatine monohydrate (CR; from 20 g down to 5 g daily), whilst the others ingested placebo (P; maltodextrin). 3. Before and after immobilization, and after 3 and 10 weeks of rehabilitation training, the cross-sectional area (CSA) of the quadriceps muscle was assessed by NMR imaging. In addition, an isokinetic dynamometer was used to measure maximal knee-extension power (Wmax), and needle biopsy samples taken from the vastus lateralis muscle were examined to asses expression of the myogenic transcription factors MyoD, myogenin, Myf5, and MRF4, and muscle fibre diameters. 4. Immobilization decreased quadriceps muscle CSA (approximately 10 %) and Wmax (approximately 25 %) by the same magnitude in both groups. During rehabilitation, CSA and Wmax recovered at a faster rate in CR than in P (P < 0.05 for both parameters). Immobilization changed myogenic factor protein expression in neither P nor CR. However, after rehabilitation myogenin protein expression was increased in P but not in CR (P < 0.05), whilst MRF4 protein expression was increased in CR but not in P (P < 0.05). In addition, the change in MRF4 expression was correlated with the change in mean muscle fibre diameter (r = 0.73, P < 0.05). 5. It is concluded that oral creatine supplementation stimulates muscle hypertrophy during rehabilitative strength training. This effect may be mediated by a creatine-induced change in MRF4 and myogenin expression.

Indexed as

DNA-Binding ProteinsTrans-ActivatorsAdenosine TriphosphateAdministration, OralAdultAtrophyBody WeightCreatineDouble-Blind MethodExercise TherapyFemaleHumansImmobilizationMaleMuscle Fibers, SkeletalMuscle ProteinsAdenosine TriphosphateCreatineDNA-Binding ProteinsMuscle ProteinsMYF5 protein, humanMyoD Proteinmyogenic factor 6Myogenic Regulatory Factor 5Myogenic Regulatory FactorsMyogeninMYOG protein, humanTrans-Activators

Identifiers

PMID11600695
PMCPMC2278864
OpenAlexW1993444633

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.