ReviewProceedings. Biological sciences2001
The role of antigenic stimulation and cytotoxic T cell activity in regulating the long-term immunopathogenesis of HIV: mechanisms and clinical implications.
Review in Proceedings. Biological sciences, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Modeling the immune response to HIV infection.Current opinion in systems biology · 2018Article
- Large Variations in HIV-1 Viral Load Explained by Shifting-Mosaic Metapopulation Dynamics.PLoS biology · 2016Article
- Backward bifurcations, turning points and rich dynamics in simple disease models.Journal of mathematical biology · 2016Article
- Effects of neutralizing antibodies on escape from CD8+ T-cell responses in HIV-1 infection.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Modeling the within-host dynamics of HIV infection.BMC biology · 2013Review
- Immune activation promotes evolutionary conservation of T-cell epitopes in HIV-1.PLoS biology · 2013Article
- Review
- Transmission selects for HIV-1 strains of intermediate virulence: a modelling approach.PLoS computational biology · 2011Article
- A stochastic model of latently infected cell reactivation and viral blip generation in treated HIV patients.PLoS computational biology · 2011Article
- Modeling latently infected cell activation: viral and latent reservoir persistence, and viral blips in HIV-infected patients on potent therapy.PLoS computational biology · 2009Article
- Modeling HIV persistence, the latent reservoir, and viral blips.Journal of theoretical biology · 2009Review
- Asymmetric division of activated latently infected cells may explain the decay kinetics of the HIV-1 latent reservoir and intermittent viral blips.Mathematical biosciences · 2009Article
- Late entry to HIV care limits the impact of anti-retroviral therapy in The Netherlands.PloS one · 2008Article
- The impact of monitoring HIV patients prior to treatment in resource-poor settings: insights from mathematical modelling.PLoS medicine · 2008Article
- Variation in HIV-1 set-point viral load: epidemiological analysis and an evolutionary hypothesis.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Transient viremia, plasma viral load, and reservoir replenishment in HIV-infected patients on antiretroviral therapy.Journal of acquired immune deficiency syndromes (1999) · 2007Article
- Role of avidity and breadth of the CD4 T cell response in progression to AIDS.Proceedings. Biological sciences · 2006Article
- Quantification of intrinsic residual viral replication in treated HIV-infected patients.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper develops a predictive mathematical model of cell infection, host immune response and viral replication that reproduces observed long-term trends in human immunodeficiency virus (HIV) pathogenesis. Cell activation induced by repeated exposure to many different antigens is proposed as the principal mechanism of providing target cells for HIV infection and, hence, of CD4+ T cell depletion, with regulation of the overall T cell pool size causing concomitant CD8 pool increases. The model correctly predicts the cross-patient variability in disease progression, the rate of which is found to depend on the efficacy of anti-HIV cytotoxic T lymphocyte responses, overall viral pathogenicity and random effects. The model also predicts a variety of responses to anti-viral therapy, including episodic residual viral replication and discordant responses and we find that such effects can be suppressed by increasing the potency of treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.