ArticleCell stress & chaperones2001
Presence of antibody against the inducible Hsp71 in patients with acute heat-induced illness.
Article in Cell stress & chaperones, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- MaPom1, a Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase, Positively Regulates Thermal and UV-B Tolerance inInternational journal of molecular sciences · 2024Article
- Antibodies to Heat Shock Proteins 90α and 90β in Psoriasis.Archivum immunologiae et therapiae experimentalis · 2020Article
- HspA1A facilitates DNA repair in human bronchial epithelial cells exposed to Benzo[a]pyrene and interacts with casein kinase 2.Cell stress & chaperones · 2014Article
- Significance of serum antibodies against HSP 60 and HSP 70 for the diagnostic of infectious diseases.Virulence · 2014Article
- Genotoxicity and reduced heat shock protein 70 in human airway smooth muscle cells exposed to cigarette smoke extract.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2013Article
- Hsp-72, a candidate prognostic indicator of heatstroke.Cell stress & chaperones · 2010Article
- Antibodies against heat shock proteins in environmental stresses and diseases: friend or foe?Cell stress & chaperones · 2006Review
- Overexpressed heat shock protein 70 protects cells against DNA damage caused by ultraviolet C in a dose-dependent manner.Cell stress & chaperones · 2006Article
- Plasma antibodies against heat shock protein 70 correlate with the incidence and severity of asthma in a Chinese population.Respiratory research · 2005Article
- Serum and lymphocyte levels of heat shock protein 70 in aging: a study in the normal Chinese population.Cell stress & chaperones · 2004Article
- Expression of the 60 kDa and 71 kDa heat shock proteins and presence of antibodies against the 71 kDa heat shock protein in pediatric patients with immune thrombocytopenic purpura.BMC blood disorders · 2004Article
- Expression of HSP70 in peripheral lymphocytes of the patients with allergic rhinitis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2003Article
- Basal and inducible levels of Hsp70 in patients with acute heat illness induced during training.Cell stress & chaperones · 2003Article
- Association of HSP70 and genotoxic damage in lymphocytes of workers exposed to coke-oven emission.Cell stress & chaperones · 2002Article
- Effect of manganese on heat stress protein synthesis of new-born rats.World journal of gastroenterology · 2002Article
- Molecular biology of stress responses.Cell stress & chaperones · 2002Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibodies against heat shock or stress proteins (Hsps) have been reported in a number of diseases in which they may be involved in the pathogenesis of the disease or may be of use for prognosis. Heat-induced diseases, such as heat cramps, heat exhaustion, or heat stroke, are frequent in hot working or living environments. There are still few investigations on the presence and possible significance of autoantibodies against Hsps in heat-induced illnesses. Using an immunoblotting technique with recombinant human Hsps, we analyzed the presence and titers of antibodies against Hsp60, Hsp71, and Hsp90alpha, and Hsp90beta in a group of 42 young male patients who presented with acute heat-induced illness during training. We also examined the presence of antibody against Hsp71 in a second group of 57 patients with acute heat-induced illness and measured the changes in titers of anti-Hsp71 antibodies in 9 patients hospitalized by emergency physicians. In the first group of young persons exercising in a hot environment, the occurrence of antibodies against Hsp71 and Hsp90alpha was significantly higher among individuals with symptoms of heat-induced illness (P < 0.05) than in the matched group of nonaffected exercising individuals. Moreover titers of antibody against Hsp71 were higher in individuals of the severe and mild heat-induced illness groups, the highest titer being found in the most severe cases. The results from the second group of 57 heat-affected patients exposed to extreme heat were similar. Again, patients with the more severe heat-induced symptoms showed a significantly higher incidence of antibodies to Hsp71 than controls and the titer of anti-Hsp71 was higher in the severely affected group. Finally, in a study of 9 patients, it was observed that the titer of anti-Hsp71 decreased during recovery from severe heat symptoms. These results suggest that measurement of antibodies to Hsps may be useful in assessing how individuals are responding to abnormal stress within their living and working environment and may be used as one biomarker to evaluate their susceptibility to heat-induced diseases.
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