ArticleAmerican journal of human genetics2001
A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions.
Article in American journal of human genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed.
- Analysis of global DNA methylation and epigenetic modifiers (DNMTs and HDACs) in human foetal endothelium exposed to gestational and type 2 diabetes.Epigenetics · 2023Article
- Type 1 diabetes genome-wide association studies: not to be lost in translation.Clinical & translational immunology · 2017Review
- Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells.Molecular metabolism · 2017Review
- Association of serum microRNAs with islet autoimmunity, disease progression and metabolic impairment in relatives at risk of type 1 diabetes.Diabetologia · 2017Article
- Association of CD247 (CD3ζ) gene polymorphisms with T1D and AITD in the population of northern Sweden.BMC medical genetics · 2016Article
- Clinical Case of Immune Dysregulation, Polyendocrinopaty, Enteropathy, X-Linked (IPEX) Syndrome with Severe Immune Deficiency and Late Onset of Endocrinopathy and Enteropathy.Case reports in medicine · 2014Article
- Epigenetic regulation of pancreatic islets.Current diabetes reports · 2013Review
- Genes involved in type 1 diabetes: an update.Genes · 2013Article
- Histone deacetylases as targets for treatment of multiple diseases.Clinical science (London, England : 1979) · 2013Review
- Assessment of type 1 diabetes risk conferred by HLA-DRB1, INS-VNTR and PTPN22 genes using the Bayesian network approach.PloS one · 2013Article
- Age-dependent variation of genotypes in MHC II transactivator gene (CIITA) in controls and association to type 1 diabetes.Genes and immunity · 2012Article
- Co-location of HDAC2 and insulin signaling components in the adult mouse hippocampus.Cellular and molecular neurobiology · 2012Article
- Endoplasmic reticulum stress in the β-cell pathogenesis of type 2 diabetes.Experimental diabetes research · 2012Review
- Article
- Genetics of type 1 diabetes: what's next?Diabetes · 2010Review
- Expression profiling of human genetic and protein interaction networks in type 1 diabetes.PloS one · 2009Article
- Approaches in type 1 diabetes research: A status report.International journal of diabetes in developing countries · 2009Article
- Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium.Diabetes · 2009Article
- Article
- Posttranslational Protein Modifications in Type 1 Diabetes - Genetic Studies with PCMT1, the Repair Enzyme Protein Isoaspartate Methyltransferase (PIMT) Encoding Gene.The review of diabetic studies : RDS · 2008Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
Type 1 diabetes mellitus (TIDM) has a multifactorial etiology, with major genetic-susceptibility determinants located in the HLA and insulin-gene (INS) regions. Linkage data implicating other disease-susceptibility loci are conflicting. This is likely due to (1) the limited power for detection of contributions of additional susceptibility loci, given the limited number of informative families available for study, (2) factors such as genetic heterogeneity between populations, and (3) potential gene-gene and gene-environment interactions. To circumvent some of these problems, we have conducted a genomewide linkage analysis for T1DM-susceptibility loci in 408 multiplex families from Scandinavia, a population expected to be homogeneous for genetic and environmental factors. In addition to verifying the HLA and INS susceptibility loci, the study provides confirmation of IDDM15 on chromosome 6q21. Suggestive evidence of additional susceptibility loci was found on chromosomes 2p, 5q, and 16p. For some loci, the support for linkage increased substantially when families were stratified on the basis of HLA or INS genotypes, with statistically significant heterogeneity between the stratified subgroups. Our data support both the existence of non-HLA genes of significance for T1DM and interaction between HLA and non-HLA loci in the determination of the T1DM phenotype.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.