ArticleMolecular biology of the cell2001
On the evolutionary conservation of the cell death pathway: mitochondrial release of an apoptosis-inducing factor during Dictyostelium discoideum cell death.
Article in Molecular biology of the cell, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 152 citations in OpenAlex.
- Eukaryotic domestication of a bacterial immune protein following horizontal transfer.bioRxiv : the preprint server for biology · 2026Article
- Perillaldehyde Functions as a Potential Antifungal Agent by Triggering Metacaspase-Independent Apoptosis in Botrytis cinerea.Microbiology spectrum · 2023Article
- The Ancient Origins of Death Domains Support the 'Original Sin' Hypothesis for the Evolution of Programmed Cell Death.Journal of molecular evolution · 2022Article
- A Conserved Role for LRRK2 and Roco Proteins in the Regulation of Mitochondrial Activity.Frontiers in cell and developmental biology · 2021Article
- Article
- Interplay of mesoscale physics and agent-like behaviors in the parallel evolution of aggregative multicellularity.EvoDevo · 2020Review
- Symbiotic Origin of Apoptosis.Results and problems in cell differentiation · 2020Article
- Cell Death in Evolutionary Transitions in Individuality.The Yale journal of biology and medicine · 2019Review
- Review
- The Anti-Cancer Effects of Frondoside A.Marine drugs · 2018Review
- Evidence that differentiation-inducing factor-1 controls chemotaxis and cell differentiation, at least in part, via mitochondria inBiology open · 2017Article
- Early nucleolar disorganization in Dictyostelium cell death.Cell death & disease · 2017Article
- Apoptosis-like cell death pathways in the unicellular parasite Toxoplasma gondii following treatment with apoptosis inducers and chemotherapeutic agents: a proof-of-concept study.Apoptosis : an international journal on programmed cell death · 2013Article
- Assets of the non-pathogenic microorganismF1000Research · 2013Review
- Programmed cell death in Leishmania: biochemical evidence and role in parasite infectivity.Frontiers in cellular and infection microbiology · 2012Review
- Apoptosis-inducing factor: structure, function, and redox regulation.Antioxidants & redox signaling · 2011Review
- Evolution of apoptosis-like programmed cell death in unicellular protozoan parasites.Parasites & vectors · 2011Review
- The melanoma-associated transmembrane glycoprotein Gpnmb controls trafficking of cellular debris for degradation and is essential for tissue repair.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Role of apoptosis-inducing factor (AIF) in programmed nuclear death during conjugation in Tetrahymena thermophila.BMC cell biology · 2010Article
- The Legionella pneumophila replication vacuole: making a cosy niche inside host cells.Nature reviews. Microbiology · 2009Review
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondria play a pivotal role in apoptosis in multicellular organisms by releasing apoptogenic factors such as cytochrome c that activate the caspases effector pathway, and apoptosis-inducing factor (AIF) that is involved in a caspase-independent cell death pathway. Here we report that cell death in the single-celled organism Dictyostelium discoideum involves early disruption of mitochondrial transmembrane potential (DeltaPsim) that precedes the induction of several apoptosis-like features, including exposure of the phosphatidyl residues at the external surface of the plasma membrane, an intense vacuolization, a fragmentation of DNA into large fragments, an autophagy, and the release of apoptotic corpses that are engulfed by neighboring cells. We have cloned a Dictyostelium homolog of mammalian AIF that is localized into mitochondria and is translocated from the mitochondria to the cytoplasm and the nucleus after the onset of cell death. Cytoplasmic extracts from dying Dictyostelium cells trigger the breakdown of isolated mammalian and Dictyostelium nuclei in a cell-free system, and this process is inhibited by a polyclonal antibody specific for Dictyostelium discoideum apoptosis-inducing factor (DdAIF), suggesting that DdAIF is involved in DNA degradation during Dictyostelium cell death. Our findings indicate that the cell death pathway in Dictyostelium involves mitochondria and an AIF homolog, suggesting the evolutionary conservation of at least part of the cell death pathway in unicellular and multicellular organisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.