ArticleInfection and immunity2001
Relative importance of NF-kappaB p50 in mycobacterial infection.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Association of Interferon Gamma +874T/A Polymorphism and Leukemia Risk: A Meta-Analysis.Medicine · 2016Pooled it
- Nuclear Factor κB Signaling Deficiency in CD11c-Expressing Phagocytes Mediates Early Inflammatory Responses and Enhances Mycobacterium tuberculosis Control.The Journal of infectious diseases · 2024Article
- Inhibition of host PARP1 contributes to the anti-inflammatory and antitubercular activity of pyrazinamide.Nature communications · 2023Article
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- Is the course of COVID-19 associated with tuberculin skin test diameter? A retrospective study.Journal of medical virology · 2022Article
- Transcription factor MAFB controls type I and II interferon response-mediated host immunity inFrontiers in microbiology · 2022Article
- Intranasal immunization with peptide-based immunogenic complex enhances BCG vaccine efficacy in a murine model of tuberculosis.JCI insight · 2021Article
- Bhlhe40 is an essential repressor of IL-10 duringThe Journal of experimental medicine · 2018Article
- Exome Sequencing Identifies a NovelFrontiers in immunology · 2017Article
- Analysis of Differentially Expressed Proteins inBioMed research international · 2017Article
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- Network Analysis of Human Genes Influencing Susceptibility to Mycobacterial Infections.PloS one · 2016Article
- Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection.Infection and immunity · 2015Article
- MPT64 protein from Mycobacterium tuberculosis inhibits apoptosis of macrophages through NF-kB-miRNA21-Bcl-2 pathway.PloS one · 2014Article
- Inhibition of nuclear factor-kappa B activation decreases survival of Mycobacterium tuberculosis in human macrophages.PloS one · 2013Article
- Characterization of NLRP12 during the in vivo host immune response to Klebsiella pneumoniae and Mycobacterium tuberculosis.PloS one · 2013Article
- Involvement of Stat1 in the phagocytosis of M. avium.Clinical & developmental immunology · 2012Article
- NF-κB Signaling Dynamics Play a Key Role in Infection Control in Tuberculosis.Frontiers in physiology · 2012Article
- Mitogen-activated protein kinases and NFkappaB are involved in SP-A-enhanced responses of macrophages to mycobacteria.Respiratory research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To understand the role of NF-kappaB in the development of murine tuberculosis in vivo, NF-kappaB p50 knockout mice were infected with Mycobacterium tuberculosis by placing them in the exposure chamber of an airborne-infection apparatus. These mice developed multifocal necrotic pulmonary lesions or lobar pneumonia. Compared with the levels in wild-type mice, pulmonary inducible nitric oxide synthase, interleukin-2 (IL-2), gamma interferon, and tumor necrosis factor alpha mRNA levels were significantly low but expression of IL-10 and transforming growth factor beta mRNAs were within the normal ranges. The pulmonary IL-6 mRNA expression level was higher. Therefore, NF-kappaB and its interaction with host cells play an important role in the pathogenesis of tuberculosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.