ArticleInfection and immunity2001
Determination of the infectious dose of Helicobacter pylori during primary and secondary infection in rhesus monkeys (Macaca mulatta).
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Clinical Management of Helicobacter Infection in Captive Baboons (Papio anubis and Papio hamadryas), and Isolation and Molecular Characterization of Three Novel Helicobacter Species.Journal of medical primatology · 2026Article
- Animal models and pathogenesis of gastric cancer: from premalignant conditions-to-metastasis.Cancer biology & medicine · 2026Review
- Research advances of the establishment and characterization ofFrontiers in microbiology · 2025Review
- A critical review onFrontiers in cellular and infection microbiology · 2025Review
- Helicobacter pylori infection in infant rhesus macaque monkeys is associated with an altered lung and oral microbiome.Scientific reports · 2024Article
- Potentially InfectiousIranian journal of public health · 2023Article
- Occurrence of cagAScientific reports · 2018Article
- Dynamic Expression of the BabA Adhesin and Its BabB Paralog during Helicobacter pylori Infection in Rhesus Macaques.Infection and immunity · 2017Article
- Article
- Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori.Cell host & microbe · 2016Article
- Identification of bacterial infection in neotropical primates.Microbial ecology · 2013Article
- Graphene-based wireless bacteria detection on tooth enamel.Nature communications · 2012Article
- Immune subversion and quorum-sensing shape the variation in infectious dose among bacterial pathogens.PLoS pathogens · 2012Article
- Use of real-time, label-free analysis in revealing low-affinity binding to blood group antigens by Helicobacter pylori.Analytical chemistry · 2011Article
- Expression of the BabA adhesin during experimental infection with Helicobacter pylori.Infection and immunity · 2010Article
- Inhibition of heat shock protein expression by Helicobacter pylori.Microbial pathogenesis · 2009Article
- Failure to detect Helicobacter pylori DNA in drinking and environmental water in Dhaka, Bangladesh, using highly sensitive real-time PCR assays.Applied and environmental microbiology · 2009Article
- Gastric helicobacters in domestic animals and nonhuman primates and their significance for human health.Clinical microbiology reviews · 2009Review
- Helicobacter pylori induces an antimicrobial response in rhesus macaques in a cag pathogenicity island-dependent manner.Gastroenterology · 2008Article
- Acquisition of Helicobacter pylori infection in rhesus macaques is most consistent with oral-oral transmission.Journal of clinical microbiology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We sought to determine the infectious dose of Helicobacter pylori during primary and secondary infection in the rhesus monkey and to determine whether preinoculation acid suppression is necessary to produce colonization. Mixed inoculation with three human-derived strains showed that H. pylori J166 is particularly adapted to colonization of rhesus monkeys, since it outcompeted two other strains. The minimum infectious dose of H. pylori J166 was 10(4) bacteria in specific-pathogen (H. pylori)-free monkeys. Rechallenge of these monkeys after antibiotic therapy was characterized by a 10- to 100-fold decrease in bacterial load compared to primary infection, but with little change in the infectious dose. Acid suppression prior to inoculation was not necessary for colonization to occur. These results provide a basis for future animal experiments using more ecologically relevant conditions of inoculation and suggest that reduction in bacterial load rather than complete protection may be a more realistic goal for H. pylori vaccination.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.