ArticleInfection and immunity2001
Involvement of fungal cell wall components in adhesion of Sporothrix schenckii to human fibronectin.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- Article
- Genetic Manipulation inJournal of fungi (Basel, Switzerland) · 2026Review
- Article
- Silencing ofJournal of fungi (Basel, Switzerland) · 2025Article
- Extracutaneous sporotrichosis.Clinical microbiology reviews · 2025Review
- Article
- Impact of Copper(II) and Silver(I) Complexes Containing 1,10-phenanthroline-5,6-dione on Cellular and Virulence Aspects ofCurrent topics in medicinal chemistry · 2025Article
- Silencing ofJournal of fungi (Basel, Switzerland) · 2024Article
- Fibronectin-binding molecules of Scedosporium apiospermum: focus on adhesive events.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Fungal Glycosidases inJournal of fungi (Basel, Switzerland) · 2023Review
- Innate Immune Responses to Sporothrix schenckii: Recognition and Elimination.Mycopathologia · 2023Review
- Virulence Factors ofJournal of fungi (Basel, Switzerland) · 2022Review
- The Heat Shock Protein 60 and Pap1 Participate in theJournal of fungi (Basel, Switzerland) · 2021Article
- Review
- Host cell invasion by medically important fungi.Cold Spring Harbor perspectives in medicine · 2014Review
- The predominance of alternatively activated macrophages following challenge with cell wall peptide-polysaccharide after prior infection with Sporothrix schenckii.Mycopathologia · 2013Article
- Article
- Sporothrix schenckii and Sporotrichosis.Clinical microbiology reviews · 2011Review
- Role of host glycosphingolipids on Paracoccidioides brasiliensis adhesion.Mycopathologia · 2011Article
- Cell wall glycoproteins participate in the adhesion of Sporothrix schenckii to epithelial cells.Mycopathologia · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic sporotrichosis is an emerging infection potentially fatal for immunocompromised patients. Adhesion to extracellular matrix proteins is thought to play a crucial role in invasive fungal diseases. Here we report studies of the adhesion of Sporothrix schenckii to the extracellular protein fibronectin (Fn). Both yeast cells and conidia of S. schenckii were able to adhere to Fn as detected by enzyme-linked immunosorbent binding assays. Adhesion of yeast cells to Fn is dose dependent and saturable. S. schenckii adheres equally well to 40-kDa and 120-kDa Fn proteolytic fragments. While adhesion to Fn was increased by Ca(2+), inhibition assays demonstrated that it was not RGD dependent. A carbohydrate-containing cell wall neutral fraction blocked up to 30% of the observed adherence for the yeast cells. The biochemical nature of this fraction suggests the participation of cell surface glycoconjugates in binding by their carbohydrate or peptide moieties. These results provide new data concerning S. schenckii adhesion mechanisms, which could be important in host-fungus interactions and the establishment of sporotrichosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.