ArticleThe EMBO journal2001
Brinker requires two corepressors for maximal and versatile repression in Dpp signalling.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 87 citations in OpenAlex.
- Biochemical principles of SMAD signaling across the animal kingdom.The Biochemical journal · 2026Review
- Review
- Normal cell cycle progression requires negative regulation of E2F1 by Groucho during S phase and its relief at G2 phase.Development (Cambridge, England) · 2023Article
- Armadillo regulates nociceptive sensitivity in the absence of injury.Molecular pain · 2022Article
- brinker levels regulated by a promoter proximal element support germ cell homeostasis.Development (Cambridge, England) · 2022Article
- Limited Availability of General Co-Repressors Uncovered in an Overexpression Context during Wing Venation inGenes · 2020Article
- Phenotypically distinct female castes in honey bees are defined by alternative chromatin states during larval development.Genome research · 2018Article
- Article
- Ras-Erk signaling induces phosphorylation of human TLE1 and downregulates its repressor function.Oncogene · 2017Article
- Mechanisms of Groucho-mediated repression revealed by genome-wide analysis of Groucho binding and activity.BMC genomics · 2017Article
- The Central Region of the Drosophila Co-repressor Groucho as a Regulatory Hub.The Journal of biological chemistry · 2015Article
- The Groucho/Transducin-like enhancer of split protein family in animal development.IUBMB life · 2015Review
- The Groucho protein Grg4 suppresses Smad7 to activate BMP signaling.Biochemical and biophysical research communications · 2013Article
- Brinker possesses multiple mechanisms for repression because its primary co-repressor, Groucho, may be unavailable in some cell types.Development (Cambridge, England) · 2013Article
- The unconserved groucho central region is essential for viability and modulates target gene specificity.PloS one · 2012Article
- A dissection of the teashirt and tiptop genes reveals a novel mechanism for regulating transcription factor activity.Developmental biology · 2011Article
- Transcriptional repression: conserved and evolved features.Current biology : CB · 2010Review
- Groucho-mediated repression may result from a histone deacetylase-dependent increase in nucleosome density.PloS one · 2010Article
- Groucho corepressor functions as a cofactor for the Knirps short-range transcriptional repressor.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Multifactorial regulation of a hox target gene.PLoS genetics · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
decapentaplegic (dpp) encodes a Drosophila transforming growth factor-beta homologue that functions as a morphogen in the developing embryo and in adult appendage formation. In the wing imaginal disc, a Dpp gradient governs patterning along the anteroposterior axis by inducing regional expression of diverse genes in a concentration-dependent manner. Recent studies show that responses to graded Dpp activity also require an input from a complementary and opposing gradient of Brinker (Brk), a transcriptional repressor protein encoded by a Dpp target gene. Here we show that Brk harbours a functional and transferable repression domain, through which it recruits the corepressors Groucho and CtBP. By analysing transcriptional outcomes arising from the genetic removal of these corepressors, and by ectopically expressing Brk variants in the embryo, we demonstrate that these corepressors are alternatively used by Brk for repressing some Dpp-responsive genes, whereas for repressing other distinct target genes they are not required. Our results show that Brk utilizes multiple means to repress its endogenous target genes, allowing repression of a multitude of complex Dpp target promoters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.