ReviewBreast cancer research : BCR2001
Hypoxia and oxidative stress. Tumour hypoxia--therapeutic considerations.
Review in Breast cancer research : BCR, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00405678 (The Effects of Exercise Training on Tumor Vascularity and Response to Neoadjuvant Therapy in Operable Breast Cancer), which is not on this map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Exercise Training on Tumor Vascularity and Response to Neoadjuvant Therapy in Operable Breast Cancer: A Phase I-II Study
Who cites it
27 citing papers in PubMed.
- Prediction of tumour hypoxia status from the washout of positron emitters in beam-monitoring PET: carbon-ion irradiation to tumour rat models.EJNMMI research · 2026Article
- Tumor-derived exosomes in hypoxic microenvironment: release mechanism, biological function and clinical application.Journal of Cancer · 2022Review
- Flavylium-Based Hypoxia-Responsive Probe for Cancer Cell Imaging.Molecules (Basel, Switzerland) · 2021Article
- Hypoxia-Driven Effects in Cancer: Characterization, Mechanisms, and Therapeutic Implications.Cells · 2021Review
- The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment.Cancer cell international · 2021Review
- Mimicking Tumor Hypoxia in Non-Small Cell Lung Cancer Employing Three-Dimensional In Vitro Models.Cells · 2021Review
- Particle Therapy for Breast Cancer: Benefits and Challenges.Frontiers in oncology · 2021Review
- Hydrated electrons induce the formation of interstrand cross-links in DNA modified by cisplatin adducts.Journal of radiation research · 2020Article
- Bioengineering the Oxygen-Deprived Tumor Microenvironment Within a Three-Dimensional Platform for Studying Tumor-Immune Interactions.Frontiers in bioengineering and biotechnology · 2020Article
- Hypoxia-Modified Cancer Cell Metabolism.Frontiers in cell and developmental biology · 2019Review
- RRx-001, A novel dinitroazetidine radiosensitizer.Investigational new drugs · 2016Review
- MALDI-Mass Spectrometric Imaging Revealing Hypoxia-Driven Lipids and Proteins in a Breast Tumor Model.Analytical chemistry · 2015Article
- Investigation into the potential for hypoxic interior of neoplasms to enhance HSPA expression in glioma.Molecular and cellular biochemistry · 2014Article
- MicroRNA-769-3p down-regulates NDRG1 and enhances apoptosis in MCF-7 cells during reoxygenation.Scientific reports · 2014Article
- Hypoxia and DNA repair.The Yale journal of biology and medicine · 2013Article
- The enzymatic activity of apoptosis-inducing factor supports energy metabolism benefiting the growth and invasiveness of advanced prostate cancer cells.The Journal of biological chemistry · 2012Article
- Localized hypoxia results in spatially heterogeneous metabolic signatures in breast tumor models.Neoplasia (New York, N.Y.) · 2012Article
- Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP.Nucleic acids research · 2012Article
- Six degrees of separation: the oxygen effect in the development of radiosensitizers.Translational oncology · 2011Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Conclusive research has shown that regions of acute/chronic hypoxia, which exist within the majority of solid tumours, have a profound influence on the therapeutic outcome of cancer chemotherapy and radiotherapy and are a strong prognostic factor of disease progression and survival. A strong argument therefore exists for assessing the hypoxic fraction of tumours, prior to patient treatment, and to tailor this treatment accordingly. Tumour hypoxia also provides a powerful physiological stimulus that can be exploited as a tumour-specific condition, allowing for the rationale design of hypoxia-activated anticancer drugs or novel hypoxia-regulated gene therapy strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.