Evidence map›Paper›PMID 11593428›Full record

ArticleOncogene2001

Oral cancer in vivo gene expression profiling assisted by laser capture microdissection and microarray analysis.

I Alevizos, M Mahadevappa, X Zhang, H Ohyama, Y Kohno, M Posner, G T Gallagher, M Varvares, D Cohen, D Kim and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 1 synthesis or guideline pooled it, 233 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Periodontitis and progression of gastrointestinal cancer: current knowledge and future perspective.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. IL-1/IL-1R Signaling in Head and Neck Cancer.Frontiers in oral health · 2021
    Review
  13. Article
  14. Review
  15. Article
  16. The Long Noncoding RNA, LINC01555, Promotes Invasion and Metastasis of Colorectal Cancer by Activating the Neuropeptide, Neuromedin U.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
  17. World journal of clinical cases · 2019
    Review
  18. Article
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 3 countries.

I AlevizosDepartment of Oral Medicine and Diagnostic Sciences, Division of Oral Pathology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA.
M Mahadevappa
X Zhang
H Ohyama
Y Kohno
M Posner
G T Gallagher
M Varvares
D Cohen
D Kim
R Kent
R B Donoff
R Todd
C M Yung
J A Warrington
D T Wong
Boston University · USHarvard University · USAffymax (United States) · USChina Medical University · CNChung Shan Medical University · TWMassachusetts Eye and Ear Infirmary · USMassachusetts General Hospital · USUniversity of Nebraska Medical Center · US

Funding

HPV AND CELL CYCLE DYSREGULATION IN ORAL CANCERP01DE012467 · NIDCR · MASSACHUSETTS GENERAL HOSPITAL · PI WONG, DAVID T · 1998 to 2002
$3.2M
PILOT PROJECTSP30DE011814 · NIDCR · FORSYTH INSTITUTE · PI HAFFAJEE, ANNE DENISE · 1996 to 2001
$957k
DOC-1 GENE REGULATION IN HUMAN ORAL CANCERR29DE011983 · NIDCR · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI TODD, RANDY C. · 1997 to 2001
$108k
NIDCR NIH HHS P01 DE12467NIDCR NIH HHS P30 DE11814NIDCR NIH HHS R29 DE11983
6 · The paper itself

Abstract

Large scale gene expression profiling was carried out on laser capture microdissected (LCM) tumor and normal oral epithelial cells and analysed on high-density oligonucleotide microarrays. About 600 genes were found to be oral cancer associated. These oral cancer associated genes include oncogenes, tumor suppressors, transcription factors, xenobiotic enzymes, metastatic proteins, differentiation markers, and genes that have not been implicated in oral cancer. The database created provides a verifiable global profile of gene expression during oral carcinogenesis, revealing the potential role of known genes as well as genes that have not been previously implicated in oral cancer.

Indexed as

Oligonucleotide Array Sequence AnalysisAgedAged, 80 and overCathepsin LCathepsinsCollagenasesCysteine EndopeptidasesDatabases, FactualDNA, ComplementaryDown-RegulationEpithelial CellsFemaleHumansMaleMiddle AgedModels, BiologicalCathepsin LCathepsinsCollagenasesCTSL protein, humanCysteine EndopeptidasesDNA, ComplementaryUrokinase-Type Plasminogen Activator

Identifiers

PMID11593428
OpenAlexW1974582859

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.