ArticleProceedings of the National Academy of Sciences of the United States of America2001
Identification of a conserved erythroid specific domain of histone acetylation across the alpha-globin gene cluster.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 70 citations in OpenAlex.
- A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker.Nature communications · 2021Article
- Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.Nature cell biology · 2017Article
- Activation of the alpha-globin gene expression correlates with dramatic upregulation of nearby non-globin genes and changes in local and large-scale chromatin spatial structure.Epigenetics & chromatin · 2017Article
- The chicken erythrocyte epigenome.Epigenetics & chromatin · 2016Article
- Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR.Developmental biology · 2012Article
- Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus.PloS one · 2010Article
- Article
- BRG1 directly regulates nucleosome structure and chromatin looping of the alpha globin locus to activate transcription.Nucleic acids research · 2009Article
- DNA methylation-histone modification relationships across the desmin locus in human primary cells.BMC molecular biology · 2009Article
- The role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells.Blood · 2008Article
- Gene and genon concept: coding versus regulation. A conceptual and information-theoretic analysis of genetic storage and expression in the light of modern molecular biology.Theory in biosciences = Theorie in den Biowissenschaften · 2007Article
- Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression.The EMBO journal · 2007Article
- Active chromatin hub of the mouse alpha-globin locus forms in a transcription factory of clustered housekeeping genes.Molecular and cellular biology · 2006Article
- A CTCF-dependent silencer located in the differentially methylated area may regulate expression of a housekeeping gene overlapping a tissue-specific gene domain.Molecular and cellular biology · 2006Article
- Review
- Gene regulation and large-scale chromatin organization in the nucleus.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2006Review
- Activation of the chicken Ig-beta locus by the collaboration of scattered regulatory regions through changes in chromatin structure.Nucleic acids research · 2006Article
- Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequences.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Formation of an active tissue-specific chromatin domain initiated by epigenetic marking at the embryonic stem cell stage.Molecular and cellular biology · 2005Article
- Improvements to GALA and dbERGE II: databases featuring genomic sequence alignment, annotation and experimental results.Nucleic acids research · 2005Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
We have analyzed the pattern of core histone acetylation across 250 kb of the telomeric region of the short arm of human chromosome 16. This gene-dense region, which includes the alpha-globin genes and their regulatory elements embedded within widely expressed genes, shows marked differences in histone acetylation between erythroid and non-erythroid cells. In non-erythroid cells, there was a uniform 2- to 3-fold enrichment of acetylated histones, compared with heterochromatin, across the entire region. In erythroid cells, an approximately 100-kb segment of chromatin encompassing the alpha genes and their remote major regulatory element was highly enriched in histone H4 acetylated at Lys-5. Other lysines in the N-terminal tail of histone H4 showed intermediate and variable levels of enrichment. Similar broad segments of erythroid-specific histone acetylation were found in the corresponding syntenic regions containing the mouse and chicken alpha-globin gene clusters. The borders of these regions of acetylation are located in similar positions in all three species, and a sharply defined 3' boundary coincides with the previously identified breakpoint in conserved synteny between these species. We have therefore demonstrated that an erythroid-specific domain of acetylation has been conserved across several species, encompassing not only the alpha-globin genes but also a neighboring widely expressed gene. These results contrast with those at other clusters and demonstrate that not all genes are organized into discrete regulatory domains.
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