ArticleProceedings of the National Academy of Sciences of the United States of America2001
Distinctive higher-order chromatin structure at mammalian centromeres.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Lamin A/C directs nucleosome-scale chromatin remodeling to define early lineage segregation in mammals.bioRxiv : the preprint server for biology · 2026Article
- Single-chromosome dynamics reveals locus-dependent dynamics and chromosome territory orientation.Journal of cell science · 2023Article
- Human centromere repositioning activates transcription and opens chromatin fibre structure.Nature communications · 2022Article
- H3K9 Methyltransferases Suv39h1 and Suv39h2 Control the Differentiation of Neural Progenitor Cells in the Adult Hippocampus.Frontiers in cell and developmental biology · 2021Article
- SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria Syndrome.Nature communications · 2020Article
- Article
- Near-atomic resolution structures of interdigitated nucleosome fibres.Nature communications · 2020Article
- Liquid-like interactions in heterochromatin: Implications for mechanism and regulation.Current opinion in cell biology · 2020Review
- Chromatin Viscoelasticity Measured by Local Dynamic Analysis.Biophysical journal · 2020Article
- Modelling and DNA topology of compact 2-start and 1-start chromatin fibres.Nucleic acids research · 2019Article
- Polymer Simulations of Heteromorphic Chromatin Predict the 3D Folding of Complex Genomic Loci.Molecular cell · 2018Article
- Regulation of transcriptional activators by DNA-binding domain ubiquitination.Cell death and differentiation · 2017Article
- Coming to terms with chromatin structure.Chromosoma · 2016Review
- H3K9me3-Dependent Heterochromatin: Barrier to Cell Fate Changes.Trends in genetics : TIG · 2016Review
- Linker histone partial phosphorylation: effects on secondary structure and chromatin condensation.Nucleic acids research · 2015Article
- Structural transitions of centromeric chromatin regulate the cell cycle-dependent recruitment of CENP-N.Genes & development · 2015Article
- The chromatin architectural proteins HMGD1 and H1 bind reciprocally and have opposite effects on chromatin structure and gene regulation.BMC genomics · 2014Article
- First molecular cytogenetic high resolution characterization of the NIH 3T3 cell line by murine multicolor banding.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2013Article
- Chromatin structure outside and inside the nucleus.Biopolymers · 2013Article
- High-resolution mapping of h1 linker histone variants in embryonic stem cells.PLoS genetics · 2013Article
Corrections and comments
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The structure of the higher-order chromatin fiber has not been defined in detail. We have used a novel approach based on sucrose gradient centrifugation to compare the conformation of centromeric satellite DNA-containing higher-order chromatin fibers with bulk chromatin fibers obtained from the same mouse fibroblast cells. Our data show that chromatin fibers derived from the centromeric domain of a chromosome exist in a more condensed structure than bulk chromatin whereas pericentromeric chromatin fibers have an intermediate conformation. From the standpoint of current models, our data are interpreted to suggest that satellite chromatin adopts a regular helical conformation compatible with the canonical 30-nm chromatin fiber whereas bulk chromatin fibers appear less regularly folded and are perhaps intermittently interrupted by deformations. This distinctive conformation of the higher-order chromatin fiber in the centromeric domain of the mammalian chromosome could play a role in the formation of heterochromatin and in the determination of centromere identity.
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