Evidence map›Paper›PMID 11592767›Full record

ArticleBritish journal of cancer2001

HPV types and cofactors causing cervical cancer in Peru.

C Santos, N Muñoz, S Klug, M Almonte, I Guerrero, M Alvarez, C Velarde, O Galdos, M Castillo, J Walboomers and 2 more

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in British journal of cancer, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00925288 (Acceptability and Feasibility of a Modified HPV Vaccine Schedule in Brothel Based Female Sex Workers in Peru), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00925288 phase4completednot on this mapstarted 2009, after this paper: background citation

Acceptability and Feasibility of a Modified HPV Vaccine Schedule in Brothel Based Female Sex Workers in Peru

TypeinterventionalSponsorJohns Hopkins Bloomberg School of Public HealthRan2009 to 2011Enrolled200ConditionsHuman Papillomavirus InfectionArmsGardasil
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. The contribution of Latin American research to HPV epidemiology and natural history knowledge.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020
    Review
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  10. Article
  11. Article
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  18. Review
  19. Observational
  20. High HPV prevalence and need for ancillary care.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 4 countries.

C SantosInstituto de Enfermedades Neoplásicas Dr Eduardo Cáceres Graziani, Av. Angamos Este 2520, Lima 34, Peru.
N Muñoz
S Klug
M Almonte
I Guerrero
M Alvarez
C Velarde
O Galdos
M Castillo
J Walboomers
C Meijer
E Caceres
Instituto Nacional de Enfermedades Neoplásicas · PECentre International de Recherche sur le Cancer · FRUniversity of Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We conducted a hospital-based case-control study in Peru of 198 women with histologically confirmed cervical cancer (173 squamous cell carcinomas and 25 cases of adenocarcinoma/adenosquamous carcinoma) and 196 control women. Information on risk factors was obtained by personal interview. Using PCR-based assays on exfoliated cervical cells and biopsy specimens, HPV DNA was detected in 95.3% of women with squamous cell carcinoma and in 92.0% of women with adenocarcinoma/adenosquamous carcinoma compared with 17.7% in control women. The age-adjusted odds ratio was 116.0 (95% Cl = 48.6-276.0) for squamous cell carcinoma and 51.4 (95% Cl = 11.4-232.0) for adenocarcinoma/adenosquamous carcinoma. The commonest types in women with cervical cancer were HPV 16, 18, 31, 52 and 35. The association with the various HPV types was equally strong for the two most common types (HPV 16 and 18) as for the other less common types. In addition to HPV, long-term use of oral contraceptives and smoking were associated with an increased risk. HPV is the main cause of both squamous cell carcinoma and adenocarcinoma in Peruvian women.

Indexed as

AdenocarcinomaAdultAgedBiopsyCarcinoma, Squamous CellCase-Control StudiesContraceptives, OralDNA, ViralFemaleHumansMiddle AgedOdds RatioPapillomaviridaePapillomavirus InfectionsPeruPolymerase Chain ReactionContraceptives, OralDNA, Viral

Identifiers

PMID11592767
PMCPMC2375092
OpenAlexW2001400232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.