ArticleGenome research2001
Bayesian analysis of haplotypes for linkage disequilibrium mapping.
Article in Genome research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis.Journal of the American College of Cardiology · 2005Trial
- Tree-based QTL mapping with expected local genetic relatedness matrices.American journal of human genetics · 2023Article
- Tree-based QTL mapping with expected local genetic relatedness matrices.bioRxiv : the preprint server for biology · 2023Article
- Optimizing genomic selection in soybean: An important improvement in agricultural genomics.Heliyon · 2022Article
- Article
- Genome-wide association studies in diverse populations.Nature reviews. Genetics · 2010Review
- A novel approach for haplotype-based association analysis using family data.BMC bioinformatics · 2010Article
- The limits of fine-scale mapping.Genetic epidemiology · 2009Article
- A fast algorithm for genome-wide haplotype pattern mining.BMC bioinformatics · 2009Article
- Association mapping by generalized linear regression with density-based haplotype clustering.Genetic epidemiology · 2009Article
- A survey on haplotyping algorithms for tightly linked markers.Journal of bioinformatics and computational biology · 2008Article
- Genetic association mapping via evolution-based clustering of haplotypes.PLoS genetics · 2007Article
- Incorporating single-locus tests into haplotype cladistic analysis in case-control studies.PLoS genetics · 2007Article
- Analysis of extended HLA haplotypes in multiple sclerosis and narcolepsy families confirms a predisposing effect for the class I region in Tasmanian MS patients.Immunogenetics · 2007Article
- Whole genome association mapping by incompatibilities and local perfect phylogenies.BMC bioinformatics · 2006Article
- Association mapping with single-feature polymorphisms.Genetics · 2006Article
- Haplotype-based quantitative trait mapping using a clustering algorithm.BMC bioinformatics · 2006Article
- High-resolution recombination patterns in a region of human chromosome 21 measured by sperm typing.PLoS genetics · 2006Article
- Modeling haplotype block variation using Markov chains.Genetics · 2006Article
- Detecting genome wide haplotype sharing using SNP or microsatellite haplotype data.Human genetics · 2006Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Haplotype analysis of disease chromosomes can help identify probable historical recombination events and localize disease mutations. Most available analyses use only marginal and pairwise allele frequency information. We have developed a Bayesian framework that utilizes full haplotype information to overcome various complications such as multiple founders, unphased chromosomes, data contamination, and incomplete marker data. A stochastic model is used to describe the dependence structure among several variables characterizing the observed haplotypes, for example, the ancestral haplotypes and their ages, mutation rate, recombination events, and the location of the disease mutation. An efficient Markov chain Monte Carlo algorithm was developed for computing the estimates of the quantities of interest. The method is shown to perform well in both real data sets (cystic fibrosis data and Friedreich ataxia data) and simulated data sets. The program that implements the proposed method, BLADE, as well as the two real datasets, can be obtained from http://www.fas.harvard.edu/~junliu/TechRept/01folder/diseq_prog.tar.gz.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.