ArticleGenome research2001
Partial deletion of the bovine ED1 gene causes anhidrotic ectodermal dysplasia in cattle.
Article in Genome research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 75 citations in OpenAlex.
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- Article
- Advancements in copy number variation screening in herbivorous livestock genomes and their association with phenotypic traits.Frontiers in veterinary science · 2023Review
- A large deletion encompassing exon 2 of the ectodysplasin A (EDA) gene in a British blue crossbred calf with hypohidrotic ectodermal dysplasia.Acta veterinaria Scandinavica · 2022Article
- Distribution of Copy Number Variation in SYT11 Gene and Its Association with Growth Conformation Traits in Chinese Cattle.Biology · 2022Article
- X-Linked Hypohidrotic Ectodermal Dysplasia in Crossbred Beef Cattle Due to a Large Deletion inAnimals : an open access journal from MDPI · 2021Article
- A 44-kb deleted-type copy number variation is associated with decreasing complement component activity and calf mortality in Japanese Black cattle.BMC genomics · 2021Article
- AG3 (Bethesda, Md.) · 2019Article
- Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway.Journal of cellular and molecular medicine · 2018Article
- Identification of copy number variation in French dairy and beef breeds using next-generation sequencing.Genetics, selection, evolution : GSE · 2017Article
- Loss of maternal ANNEXIN A10 via a 34-kb deleted-type copy number variation is associated with embryonic mortality in Japanese Black cattle.BMC genomics · 2016Article
- A Splice Defect in the EDA Gene in Dogs with an X-Linked Hypohidrotic Ectodermal Dysplasia (XLHED) Phenotype.G3 (Bethesda, Md.) · 2016Article
- Genome-wide identification of copy number variation using high-density single-nucleotide polymorphism array in Japanese Black cattle.BMC genetics · 2016Article
- Genomic population structure and prevalence of copy number variations in South African Nguni cattle.BMC genomics · 2015Article
- The distribution and impact of common copy-number variation in the genome of the domesticated apple, Malus x domestica Borkh.BMC genomics · 2015Article
- Hairless Streaks in Cattle Implicate TSR2 in Early Hair Follicle Formation.PLoS genetics · 2015Article
- Genome-Wide Study of Structural Variants in Bovine Holstein, Montbéliarde and Normande Dairy Breeds.PloS one · 2015Article
- Detection of copy number variations and their effects in Chinese bulls.BMC genomics · 2014Article
- Copy number variations among silkworms.BMC genomics · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anhidrotic ectodermal dysplasia (ED1) is characterized by hypotrichosis, reduced number of sweat glands, and incisior anodontia in human, mouse, and cattle. In affected humans and mice, mutations in the ED1 gene coding for ectodysplasin 1 are found. Ectodysplasin 1 is a novel trimeric transmembrane protein with an extracellular TNF-like signaling domain that is believed to be involved in the formation of hair follicles and tooth buds during fetal development. We report the construction of a 480-kb BAC contig harboring the complete bovine ED1 gene on BTA Xq22-Xq24. Physical mapping and sequence analysis of the coding parts of the ED1 gene revealed that a large genomic region including exon 3 of the ED1 gene is deleted in cattle with anhidrotic ectodermal dysplasia in a family of German Holstein cattle with three affected maternal half sibs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.