ArticleGenome research2001
Evolutionarily conserved sequences on human chromosome 21.
Article in Genome research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Conserved Noncoding Elements Evolve Around the Same Genes Throughout Metazoan Evolution.Genome biology and evolution · 2024Article
- Conserved Critical Evolutionary Gene Structures in Orthologs.Journal of molecular evolution · 2019Article
- Pairs of Adjacent Conserved Noncoding Elements Separated by Conserved Genomic Distances Act as Cis-Regulatory Units.Genome biology and evolution · 2018Article
- Apolipoprotein(a) is the Product of a Pseudogene: Implications for the Pathophysiology of Lipoprotein(a).Cureus · 2018Review
- Deep profiling of the novel intermediate-size noncoding RNAs in intraerythrocytic Plasmodium falciparum.PloS one · 2014Article
- Molecular hyperdiversity and evolution in very large populations.Molecular ecology · 2013Article
- Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2.Nature reviews. Neuroscience · 2012Review
- Systematic prediction of cis-regulatory elements in the Chlamydomonas reinhardtii genome using comparative genomics.Plant physiology · 2012Article
- Natural selection drives rapid evolution of mouse embryonic heart enhancers.BMC systems biology · 2012Article
- Detection of lineage-specific evolutionary changes among primate species.BMC bioinformatics · 2011Article
- Article
- The evolving role of drug metabolism in drug discovery and development.Pharmaceutical research · 2007Review
- Genomic selective constraints in murid noncoding DNA.PLoS genetics · 2006Article
- Short blocks from the noncoding parts of the human genome have instances within nearly all known genes and relate to biological processes.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy.Respiratory research · 2005Article
- Conserved sequences of prokaryotic proteomes and their compositional age.Journal of molecular evolution · 2005Article
- Evolutionary constraints in conserved nongenic sequences of mammals.Genome research · 2005Article
- A pilot study of transcription unit analysis in rice using oligonucleotide tiling-path microarray.Plant molecular biology · 2005Article
- Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes.Genome research · 2005Article
- Functional constraint and divergence in the G protein family in Caenorhabditis elegans and Caenorhabditis briggsae.Molecular genetics and genomics : MGG · 2005Article
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9 authors.
Funding
Abstract
Comparison of human sequences with the DNA of other mammals is an excellent means of identifying functional elements in the human genome. Here we describe the utility of high-density oligonucleotide arrays as a rapid approach for comparing human sequences with the DNA of multiple species whose sequences are not presently available. High-density arrays representing approximately 22.5 Mb of nonrepetitive human chromosome 21 sequence were synthesized and then hybridized with mouse and dog DNA to identify sequences conserved between humans and mice (human-mouse elements) and between humans and dogs (human-dog elements). Our data show that sequence comparison of multiple species provides a powerful empiric method for identifying actively conserved elements in the human genome. A large fraction of these evolutionarily conserved elements are present in regions on chromosome 21 that do not encode known genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.