ArticleGenome research2001
Partitioning of tissue expression accompanies multiple duplications of the Na+/K+ ATPase alpha subunit gene.
Article in Genome research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- Paralog switching facilitates diadromy: ontogenetic, microevolutionary and macroevolutionary evidence.Oecologia · 2024Article
- NaProceedings. Biological sciences · 2019Article
- Conserved noncoding sequences conserve biological networks and influence genome evolution.Heredity · 2018Article
- Short-term Effects of Hypertonic Shock on NaZoological studies · 2016Article
- Article
- Sodium pump activity in the yolk syncytial layer regulates zebrafish heart tube morphogenesis.Developmental biology · 2012Article
- Role of antioxidants on Na(+),K (+)-ATPase activity and gene expression in cerebral cortex of hyperprolinemic rats.Metabolic brain disease · 2011Article
- Distinct troponin C isoform requirements in cardiac and skeletal muscle.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- High-resolution cardiovascular function confirms functional orthology of myocardial contractility pathways in zebrafish.Physiological genomics · 2010Article
- Article
- Gene Duplication of the zebrafish kit ligand and partitioning of melanocyte development functions to kit ligand a.PLoS genetics · 2007Article
- Characterization of Na, K-ATPase genes in Atlantic salmon (Salmo salar) and comparative genomic organization with rainbow trout (Oncorhynchus mykiss).Molecular genetics and genomics : MGG · 2005Article
- Functional divergence of two zebrafish midkine growth factors following fish-specific gene duplication.Genome research · 2003Article
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4 authors.
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Abstract
Vertebrate genomes contain multiple copies of related genes that arose through gene duplication. In the past it has been proposed that these duplicated genes were retained because of acquisition of novel beneficial functions. A more recent model, the duplication-degeneration-complementation hypothesis (DDC), posits that the functions of a single gene may become separately allocated among the duplicated genes, rendering both duplicates essential. Thus far, empirical evidence for this model has been limited to the engrailed and sox family of developmental regulators, and it has been unclear whether it may also apply to ubiquitously expressed genes with essential functions for cell survival. Here we describe the cloning of three zebrafish alpha subunits of the Na(+),K(+)-ATPase and a comprehensive evolutionary analysis of this gene family. The predicted amino acid sequences are extremely well conserved among vertebrates. The evolutionary relationships and the map positions of these genes and of other alpha-like sequences indicate that both tandem and ploidy duplications contributed to the expansion of this gene family in the teleost lineage. The duplications are accompanied by acquisition of clear functional specialization, consistent with the DDC model of genome evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.