ArticleBMC microbiology2001
In vivo involvement of polymorphonuclear neutrophils in Leishmania infantum infection.
Article in BMC microbiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 73 citations in OpenAlex.
- Ex Vivo Analysis of the Association of GFP-ExpressingMicroorganisms · 2024Article
- Miltefosine enhances infectivity of a miltefosine-resistant Leishmania infantum strain by attenuating its innate immune recognition.PLoS neglected tropical diseases · 2021Article
- The Impact of Neutrophil Recruitment to the Skin on the Pathology Induced byFrontiers in immunology · 2021Review
- Leishmania major degrades murine CXCL1 - An immune evasion strategy.PLoS neglected tropical diseases · 2019Article
- Infection of Human Neutrophils WithFrontiers in cellular and infection microbiology · 2019Article
- RIPK1-RIPK3-MLKL-Associated Necroptosis DrivesFrontiers in immunology · 2018Article
- A secondary wave of neutrophil infiltration causes necrosis and ulceration in lesions of experimental American cutaneous leishmaniasis.PloS one · 2017Article
- Toll-Like Receptor 2 Is Required for Inflammatory Process Development duringFrontiers in microbiology · 2017Article
- The Equivocal Role of Th17 Cells and Neutrophils on Immunopathogenesis of Leishmaniasis.Frontiers in immunology · 2017Review
- Multicomponent LBSap vaccine displays immunological and parasitological profiles similar to those of Leish-Tec® and Leishmune® vaccines against visceral leishmaniasis.Parasites & vectors · 2016Article
- Infection and Activation of Human Neutrophils with FluorescentJournal of immunological techniques in infectious diseases · 2016Article
- Toll-like receptor 9 signaling in dendritic cells regulates neutrophil recruitment to inflammatory foci following Leishmania infantum infection.Infection and immunity · 2015Article
- Permissive and protective roles for neutrophils in leishmaniasis.Clinical and experimental immunology · 2015Review
- Exposure to Leishmania braziliensis triggers neutrophil activation and apoptosis.PLoS neglected tropical diseases · 2015Article
- Neutrophils have a protective role during early stages of Leishmania amazonensis infection in BALB/c mice.Parasite immunology · 2014Article
- The influence of early neutrophil-Leishmania interactions on the host immune response to infection.Frontiers in cellular and infection microbiology · 2012Review
- Leukocytes infiltrate the skin and draining lymph nodes in response to the protozoan Leishmania infantum chagasi.Infection and immunity · 2011Article
- Neutrophils reduce the parasite burden in Leishmania (Leishmania) amazonensis-infected macrophages.PloS one · 2010Article
- Immunological perspectives of leishmaniasis.Journal of global infectious diseases · 2010Article
- Inflammatory monocytes but not neutrophils are necessary to control infection with Toxoplasma gondii in mice.Infection and immunity · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of lymphocytes in the specific defence against L. infantum has been well established, but the part played by polynuclear neutrophil (PN) cells in controlling visceral leishmaniasis was much less studied. In this report we examine in vivo the participation of PN in early and late phases of infection by L. infantum.
resultsPromastigote phagocytosis and killing occurs very early after infection, as demonstrated by electron microscopy analyses which show in BALB/c mouse spleen, but not in liver, numerous PN harbouring ultrastructurally degraded parasites. It is shown, using mAb RB6-8C5 directed against mature mouse granulocytes, that in chronically infected mice, long-term PN depletion did not enhance parasite counts neither in liver nor in spleen, indicating that these cells are not involved in the late phase of L. infantum infection. In acute stage of infection, in mouse liver, where L. infantum load is initially larger than that in spleen but resolves spontaneously, there was no significant effect of neutrophils depletion. By contrast, early in infection the neutrophil cells crucially contributed to parasite killing in spleen, since PN depletion, performed before and up to 7 days after the parasite inoculation, resulted in a ten-fold increase of parasite burden.
conclusionsTaken together these data show that neutrophil cells contribute to the early control of the parasite growth in spleen but not in liver and that these cells have no significant effect late in infection in either of these target organs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.