ArticleAmerican journal of human genetics2001
Markers for mapping by admixture linkage disequilibrium in African American and Hispanic populations.
Article in American journal of human genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00559767 (Mapping of End Stage Renal Disease Genetic Susceptibility in African Americans by Admixture Linkage Disequilibrium), which is not on this map. Cited by 64 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mapping of End Stage Renal Disease Genetic Susceptibility in African Americans by Admixture Linkage Disequilibrium
Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 141 citations in OpenAlex.
- A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.The Journal of allergy and clinical immunology · 2013Pooled it
- Social determinants of health but not global genetic ancestry predict dementia prevalence in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Apolipoprotein E (APOE) genotype, dementia, and memory performance among Caribbean Hispanic versus US populations.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Investigation of triple-negative breast cancer risk alleles in an International African-enriched cohort.Scientific reports · 2021Article
- Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci.Human molecular genetics · 2016Article
- Selection of highly informative SNP markers for population affiliation of major US populations.International journal of legal medicine · 2016Article
- Variant Discovery and Fine Mapping of Genetic Loci Associated with Blood Pressure Traits in Hispanics and African Americans.PloS one · 2016Article
- Genetic bio-ancestry and social construction of racial classification in social surveys in the contemporary United States.Demography · 2014Article
- Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations.Genome medicine · 2014Article
- Data quality control in social surveys using genetic information.Biodemography and social biology · 2014Article
- GABRA2 markers moderate the subjective effects of alcohol.Addiction biology · 2013Article
- Human population admixture in Asia.Genomics & informatics · 2012Article
- Inferring genome-wide patterns of admixture in Qataris using fifty-five ancestral populations.BMC genetics · 2012Article
- Stronger bone correlates with African admixture in African-American women.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Evaluation of approaches for identifying population informative markers from high density SNP chips.BMC genetics · 2011Article
- Admixture mapping to identify spontaneous preterm birth susceptibility loci in African Americans.Obstetrics and gynecology · 2011Article
- Information content in genome-wide scans: concordance between patterns of genetic differentiation and linkage mapping associations.BMC genomics · 2011Article
- Admixture mapping: from paradigms of race and ethnicity to population history.The HUGO journal · 2010Article
- Comparing genetic ancestry and self-reported race/ethnicity in a multiethnic population in New York City.Journal of genetics · 2010Article
- Mapping genes that predict treatment outcome in admixed populations.The pharmacogenomics journal · 2010Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Population linkage disequilibrium occurs as a consequence of mutation, selection, genetic drift, and population substructure produced by admixture of genetically distinct ethnic populations. African American and Hispanic ethnic groups have a history of significant gene flow among parent groups, which can be of value in affecting genome scans for disease-gene discovery in the case-control and transmission/disequilibrium test designs. Disease-gene discovery using mapping by admixture linkage disequilibrium (MALD) requires a map of polymorphic markers that differentiate between the founding populations, along with differences in disease-gene allele frequencies. We describe markers appropriate for MALD mapping by assessing allele frequencies of 744 short tandem repeats (STRs) in African Americans, Hispanics, European Americans, and Asians, by choosing STR markers that have large differences in composite delta, log-likelihood ratios, and/or I*(2) for MALD. Additional markers can be added to this MALD map by utilization of the rapidly growing single-nucleotide-polymorphism databases and the literature, to achieve a 3-10-cM scanning scale. The map will be useful for studies of diseases, including prostate and breast cancer, diabetes, hypertension, and end-stage renal disease, that have large differences in incidence between the founding populations of either Hispanics or African Americans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.