ArticleAmerican journal of human genetics2001
Excess of twins among affected sibling pairs with autism: implications for the etiology of autism.
Article in American journal of human genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 85 citations in OpenAlex.
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- The Autism-Tics, ADHD and other Comorbidities inventory (A-TAC): previous and predictive validity.BMC psychiatry · 2017Article
- Investigating the validation of the Chinese Mandarin version of the Social Responsiveness Scale in a Mainland China child population.BMC psychiatry · 2017Article
- Untangling the most probable role for vitamin DDermato-endocrinology · 2017Article
- Stoppage in Autism Spectrum Disorders.Journal of autism and developmental disorders · 2015Article
- Autism phenotype versus registered diagnosis in Swedish children: prevalence trends over 10 years in general population samples.BMJ (Clinical research ed.) · 2015Article
- Impairment of translation in neurons as a putative causative factor for autism.Biology direct · 2014Article
- MicroRNA dysregulation in neuropsychiatric disorders and cognitive dysfunction.Neurobiology of disease · 2012Review
- Autism risk in small- and large-for-gestational-age infants.American journal of obstetrics and gynecology · 2012Article
- Genetic bases of stuttering: the state of the art, 2011.Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) · 2012Review
- Have secular changes in perinatal risk factors contributed to the recent autism prevalence increase? Development and application of a mathematical assessment model.Annals of epidemiology · 2011Article
- Novel variants identified in methyl-CpG-binding domain genes in autistic individuals.Neurogenetics · 2010Article
- MicroRNAs in psychiatric and neurodevelopmental disorders.Brain research · 2010Review
- The 'fractionable autism triad': a review of evidence from behavioural, genetic, cognitive and neural research.Neuropsychology review · 2008Review
- The neuropathology of autism.Brain pathology (Zurich, Switzerland) · 2007Review
- The genetics of autistic disorders and its clinical relevance: a review of the literature.Molecular psychiatry · 2007Review
- Prenatal and birth complications in autism.Maternal and child health journal · 2007Article
- The genetics of autism spectrum disorders.Neuromolecular medicine · 2006Review
- Brief report: autistic traits in twins vs. non-twins--a preliminary study.Journal of autism and developmental disorders · 2005Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
It is widely accepted that genes play a role in the etiology of autism. Evidence for this derives, in part, from twin data. However, despite converging evidence from gene-mapping studies, aspects of the genetic contribution remain obscure. In a sample of families selected because each had exactly two affected sibs, we observed a remarkably high proportion of affected twin pairs, both MZ and DZ. Of 166 affected sib pairs, 30 (12 MZ, 17 DZ, and 1 of unknown zygosity) were twin pairs. Deviation from expected values was statistically significant (P<10(-6) for all twins); in a similarly ascertained sample of individuals with type I diabetes, there was no deviation from expected values. We demonstrate that to ascribe the excess of twins with autism solely to ascertainment bias would require very large ascertainment factors; for example, affected twin pairs would need to be, on average, approximately 10 times more likely to be ascertained than affected non-twin sib pairs (or 7 times more likely if "stoppage" plays a role). Either risk factors (related to twinning or to fetal development) or other factors (genetic or nongenetic) in the parents may contribute to autism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.