ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
The enterins: a novel family of neuropeptides isolated from the enteric nervous system and CNS of Aplysia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Mechanisms that create a sequence of feeding-related behaviors in the molluskJournal of neurophysiology · 2026Article
- A brain-gut excitatory peptide/CCHamide homolog regulates satiation and motivational state transitions in the Aplysia feeding circuit.The Journal of biological chemistry · 2026Article
- Synaptic and intrinsic plasticity mediated by CCK-type signaling coordinates behavioral changes during motivational state shifts.Cell reports · 2025Article
- A Single Central Pattern Generator for the Control of a Locomotor Rolling Wave in MolluscResearch (Washington, D.C.) · 2023Article
- Profiling 26,000 Aplysia californica neurons by single cell mass spectrometry reveals neuronal populations with distinct neuropeptide profiles.The Journal of biological chemistry · 2022Article
- Identification of an allatostatin C signaling system in mollusc Aplysia.Scientific reports · 2022Article
- An Anticipatory Circuit Modification That Modifies Subsequent Task Switching.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Distribution and physiological effect of enterin neuropeptides in the olfactory centers of the terrestrial slug Limax.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- Greenlip Abalone (G3 (Bethesda, Md.) · 2019Article
- Article
- Multifaceted Expression of Peptidergic Modulation in the Feeding System of Aplysia.ACS chemical neuroscience · 2018Review
- Newly Identified Aplysia SPTR-Gene Family-Derived Peptides: Localization and Function.ACS chemical neuroscience · 2018Article
- Discovery of leucokinin-like neuropeptides that modulate a specific parameter of feeding motor programs in the molluscan model,The Journal of biological chemistry · 2017Article
- Article
- Generation of a novel monoclonal antibody that recognizes the alpha (α)-amidated isoform of a valine residue.BMC neuroscience · 2015Article
- Functional Characterization of a Vesicular Glutamate Transporter in an Interneuron That Makes Excitatory and Inhibitory Synaptic Connections in a Molluscan Neural Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Complementary interactions between command-like interneurons that function to activate and specify motor programs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Functional expression and characterization of the C. elegans G-protein-coupled FLP-2 Receptor (T19F4.1) in mammalian cells and yeast.International journal for parasitology. Drugs and drug resistance · 2013Article
- Characterization of GdFFD, a D-amino acid-containing neuropeptide that functions as an extrinsic modulator of the Aplysia feeding circuit.The Journal of biological chemistry · 2013Article
- Latent modulation: a basis for non-disruptive promotion of two incompatible behaviors by a single network state.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
To identify neuropeptides that have a broad spectrum of actions on the feeding system of Aplysia, we searched for bioactive peptides that are present in both the gut and the CNS. We identified a family of structurally related nonapeptides and decapeptides (enterins) that are present in the gut and CNS of Aplysia, and most of which share the HSFVamide sequence at the C terminus. The structure of the enterin precursor deduced from cDNA cloning predicts 35 copies of 20 different enterins. Northern analysis, in situ hybridization, and immunocytochemistry show that the enterins are abundantly present in the CNS and the gut of Aplysia. Using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry we characterized the enterin-precursor processing, demonstrated that all of the precursor-predicted enterins are present, and determined post-translational modifications of various enterins. Enterin-positive neuronal somata and processes were found in the gut, and enterins inhibited contractions of the gut. In the CNS, the cerebral and buccal ganglia, which control feeding, contained the enterins. Enterin was also present in the nerve that connects these two ganglia. Enterins reduced the firing of interneurons B4/5 during feeding motor programs. Such enterin-induced reduction of firing also occurred when excitability of B4/5 was tested directly. Because reduction of B4/5 activity corresponds to a switch from egestive to ingestive behaviors, enterin may contribute to such program switching. Furthermore, because enterins are present throughout the nervous system, they may also play a regulatory role in nonfeeding behaviors of Aplysia.
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Identifiers
11588196PMC6763844What OpenQuestion holds
Registered trials
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