ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Excitatory and inhibitory circuitry in the superficial gray layer of the superior colliculus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 66 citations in OpenAlex.
- Neuronal Features of Visual Attention in the Mouse Superior Colliculus Depend on Learned Behavioral Relevance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Genetically defined neuron types underlying visuomotor transformation in the superior colliculus.Nature reviews. Neuroscience · 2024Review
- What Are the Functions of the Superior Colliculus and Its Involvement in Neurologic Disorders?Neurology · 2023Article
- The tectum/superior colliculus as the vertebrate solution for spatial sensory integration and action.Current biology : CB · 2021Review
- Unraveling circuits of visual perception and cognition through the superior colliculus.Neuron · 2021Review
- GABAergic Transmission in the Basolateral Amygdala Differentially Modulates Plasticity in the Dentate Gyrus and the CA1 Areas.International journal of molecular sciences · 2020Article
- Oscillations in Spontaneous and Visually Evoked Neuronal Activity in the Superficial Layers of the Cat's Superior Colliculus.Frontiers in systems neuroscience · 2018Article
- Parvalbumin and GABA Microcircuits in the Mouse Superior Colliculus.Frontiers in neural circuits · 2018Article
- Circuits for Action and Cognition: A View from the Superior Colliculus.Annual review of vision science · 2017Review
- Neurons in the most superficial lamina of the mouse superior colliculus are highly selective for stimulus direction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Excitatory synaptic feedback from the motor layer to the sensory layers of the superior colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- A novel α-conotoxin MII-sensitive nicotinic acetylcholine receptor modulates [(3) H]-GABA release in the superficial layers of the mouse superior colliculus.Journal of neurochemistry · 2012Article
- Synapse maturation is enhanced in the binocular region of the retinocollicular map prior to eye opening.Journal of neurophysiology · 2012Article
- Article
- Circuit dynamics of the superior colliculus revealed by in vitro voltage imaging.Annals of the New York Academy of Sciences · 2011Article
- Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Control from below: the role of a midbrain network in spatial attention.The European journal of neuroscience · 2011Review
- Recurrent antitopographic inhibition mediates competitive stimulus selection in an attention network.Journal of neurophysiology · 2011Article
- Visual receptive field properties of neurons in the superficial superior colliculus of the mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Spatial updating in monkey superior colliculus in the absence of the forebrain commissures: dissociation between superficial and intermediate layers.Journal of neurophysiology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Stratum griseum superficiale (SGS) of the superior colliculus receives a dense cholinergic input from the parabigeminal nucleus. In this study, we examined in vitro the modulatory influence of acetylcholine (ACh) on the responses of SGS neurons that project to the visual thalamus in the rat. We used whole-cell patch-clamp recording to measure the responses of these projection neurons to electrical stimulation of their afferents in the stratum opticum (SO) before and during local pressure injections of ACh. These colliculothalamic projection neurons (CTNs) were identified during the in vitro experiments by prelabeling them from the thalamus with the retrograde axonal tracer wheat germ agglutinin-apo-HRP-gold. In a group of cells that included the prelabeled neurons, EPSCs evoked by SO stimulation were significantly reduced by the application of ACh, whereas IPSC amplitudes were significantly enhanced. Similar effects were observed when the nicotinic ACh receptor agonist lobeline was used. Application of the selective GABA(B) receptor antagonist 3-[[(3,4-dichlorophenyl)-methyl]amino]propyl](diethoxymethyl)phosphinic acid blocked ACh-induced reduction in the evoked response. In contrast, the ACh-induced reduction was insensitive to application of the GABA(A) receptor antagonist bicuculline. The ACh-induced reduction was also diminished by bath application of muscimol at the low concentrations that selectively activate GABA(C) receptors. Because GABA(C) receptors may be specifically expressed by GABAergic SGS interneurons (Schmidt et al., 2001), our results support the hypothesis that ACh reduces CTN activity by nicotinic receptor-mediated excitation of local GABAergic interneurons. These interneurons in turn use GABA(B) receptors to inhibit the CTNs.
Indexed as
Identifiers
11588187PMC6763849W1886692790What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.