ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Deposition of the NG2 proteoglycan at nodes of Ranvier in the peripheral nervous system.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 73 citations in OpenAlex.
- Mechanisms of node of Ranvier assembly.Nature reviews. Neuroscience · 2021Review
- A Subpopulation of Foxj1-Expressing, Nonmyelinating Schwann Cells of the Peripheral Nervous System Contribute to Schwann Cell Remyelination in the Central Nervous System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- NG2 Proteoglycan Enhances Brain Tumor Progression by Promoting Beta-1 Integrin Activation in both Cis and Trans Orientations.Cancers · 2017Review
- Heterogeneity of astrocyte and NG2 cell insertion at the node of ranvier.The Journal of comparative neurology · 2017Article
- The reactions and role of NG2 glia in spinal cord injury.Brain research · 2016Review
- Autoimmune antigenic targets at the node of Ranvier in demyelinating disorders.Nature reviews. Neurology · 2015Review
- Matrix metalloproteinase-14 both sheds cell surface neuronal glial antigen 2 (NG2) proteoglycan on macrophages and governs the response to peripheral nerve injury.The Journal of biological chemistry · 2015Article
- Perlecan is recruited by dystroglycan to nodes of Ranvier and binds the clustering molecule gliomedin.The Journal of cell biology · 2015Article
- Characterization of Endoneurial Fibroblast-like Cells from Human and Rat Peripheral Nerves.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2014Article
- The making of a node: a co-production of neurons and glia.Current opinion in neurobiology · 2013Review
- Neutralization of inhibitory molecule NG2 improves synaptic transmission, retrograde transport, and locomotor function after spinal cord injury in adult rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Chondroitinase ABC reduces time to muscle reinnervation and improves functional recovery after sciatic nerve transection in rats.Journal of neurophysiology · 2012Article
- Glia unglued: how signals from the extracellular matrix regulate the development of myelinating glia.Developmental neurobiology · 2011Review
- Role of chondroitin sulfate proteoglycans in axonal conduction in Mammalian spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Molecular mechanisms of node of Ranvier formation.Current opinion in cell biology · 2008Review
- Analysis of axonal regeneration in the central and peripheral nervous systems of the NG2-deficient mouse.BMC neuroscience · 2007Article
- Secreted gliomedin is a perinodal matrix component of peripheral nerves.The Journal of cell biology · 2007Article
- Chondroitinase applied to peripheral nerve repair averts retrograde axonal regeneration.Experimental neurology · 2007Article
- Oligodendrocytes regulate formation of nodes of Ranvier via the recognition molecule OMgp.Neuron glia biology · 2006Article
- Antibodies against the NG2 proteoglycan promote the regeneration of sensory axons within the dorsal columns of the spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The node of Ranvier is a complex macromolecular assembly of ion channels and other proteins that is specialized for the rapid propagation of the action potential. A full understanding of the processes responsible for the assembly and maintenance of the node requires first the identification and characterization of the proteins found there. Here we show that NG2, a structurally unique chondroitin sulfate proteoglycan, is a molecular component of the node of Ranvier in the peripheral nervous system. In adult sciatic nerve, NG2 is (1) associated with thin, elongated fibroblast-like cells, (2) on some but not all basal laminae, and (3) at nodes of Ranvier. At the nodes, NG2 is restricted to the nodal gap and is absent from the paranodal or juxtaparanodal region. In dissociated cell cultures of adult sciatic nerve, perineurial fibroblasts but not Schwann cells express NG2 on their surfaces. Approximately 45% of the total NG2 in peripheral nerves is in a soluble, rather than particulate, subcellular compartment. NG2 is also present in membrane fractions that also contain high levels of voltage-dependent sodium channels, caspr, and neuron-glia related cell adhesion molecule. These medium-density membranes likely correspond to the nodal and paranodal region of the axon-Schwann cell unit. These results suggest a model in which perineurial fibroblasts secrete or shed NG2, which subsequently associates with nodes of Ranvier. The growth-inhibitory and anti-adhesive properties of NG2 may limit the lateral extension of myelinating Schwann cells as nodes mature. NG2 may also participate in the barrier functions of the perineurial linings of the nerve.
Indexed as
Identifiers
11588184PMC6763877W2130101439What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.