ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed.
- Identification of GABBR2 as a diagnostic marker and its association with Aβ in Alzheimer's disease.Biochemistry and biophysics reports · 2025Article
- Action of GABAThe journal of physiological sciences : JPS · 2024Article
- Control of CCR5 Cell-Surface Targeting by the PRAF2 Gatekeeper.International journal of molecular sciences · 2023Article
- G protein coupling and activation of the metabotropic GABANature communications · 2022Article
- GABACurrent topics in behavioral neurosciences · 2022Review
- Mechanisms and Regulation of Neuronal GABACurrent topics in behavioral neurosciences · 2022Review
- Class A and C GPCR Dimers in Neurodegenerative Diseases.Current neuropharmacology · 2022Review
- EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia.Nature communications · 2021Article
- Structural Characterization of Receptor-Receptor Interactions in the Allosteric Modulation of G Protein-Coupled Receptor (GPCR) Dimers.International journal of molecular sciences · 2021Review
- GABABiomedicines · 2021Article
- Ectopic activation of GABANature ecology & evolution · 2021Article
- A Reversal in Hair Cell Orientation Organizes Both the Auditory and Vestibular Organs.Frontiers in neuroscience · 2021Review
- Structures of metabotropic GABANature · 2020Article
- Structure of human GABANature · 2020Article
- Article
- Cryo-EM structures of inactive and active GABACell research · 2020Article
- Using the novel HiBiT tag to label cell surface relaxin receptors for BRET proximity analysis.Pharmacology research & perspectives · 2019Article
- Structural basis for auxiliary subunit KCTD16 regulation of the GABAProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Inhibition shapes the organization of hippocampal representations.Hippocampus · 2018Review
- Structural biology of GABANeuropharmacology · 2018Review
12 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
GABA(B) receptors are unique among G-protein-coupled receptors (GPCRs) in their requirement for heterodimerization between two homologous subunits, GABA(B1) and GABA(B2), for functional expression. Whereas GABA(B1) is capable of binding receptor agonists and antagonists, the role of each GABA(B) subunit in receptor signaling is unknown. Here we identified amino acid residues within the second intracellular domain of GABA(B2) that are critical for the coupling of GABA(B) receptor heterodimers to their downstream effector systems. Our results provide strong evidence for a functional role of the GABA(B2) subunit in G-protein coupling of the GABA(B) receptor heterodimer. In addition, they provide evidence for a novel "sequential" GPCR signaling mechanism in which ligand binding to one heterodimer subunit can induce signal transduction through the second partner of a heteromeric complex.
Indexed as
Identifiers
11588177PMC6763845What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.