ArticleBritish journal of pharmacology2001
Anandamide induces cardiovascular and respiratory reflexes via vasosensory nerves in the anaesthetized rat.
Article in British journal of pharmacology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 63 citations in OpenAlex.
- Functional knockout of the TRPV1 channel has no effect on the exercise pressor reflex in rats.The Journal of physiology · 2023Article
- Cannabis and Endometriosis: The Roles of the Gut Microbiota and the Endocannabinoid System.Journal of clinical medicine · 2023Review
- Ipsilateral somatic nerves mediate histamine-induced vasosensory reflex responses involving perivascular afferents in rat models.Scientific reports · 2021Article
- Involvement of TRPV1 in the expression and release of calcitonin gene-related peptide induced by rutaecarpine.Molecular medicine reports · 2018Article
- Triphasic blood pressure responses to cannabinoids: do we understand the mechanism?British journal of pharmacology · 2012Review
- Exaggerated Pressor Response in Relation to Attenuated Muscle Temperature Response during Contraction in Ischemic Heart Failure.Frontiers in physiology · 2012Article
- Local adenosine receptor blockade accentuates the sympathetic responses to fatiguing exercise.American journal of physiology. Heart and circulatory physiology · 2010Article
- Increased GFR and renal excretory function by activation of TRPV1 in the isolated perfused kidney.Pharmacological research · 2008Article
- The group IV afferent neuron expresses multiple receptor alterations in cardiomyopathyic rats: evidence at the cannabinoid CB1 receptor.The Journal of physiology · 2008Article
- In vivo effects of CB2 receptor-selective cannabinoids on the vasculature of normal and arthritic rat knee joints.British journal of pharmacology · 2008Article
- Effects of chronic nitric oxide synthase inhibition on the cardiovascular responses to cannabinoids in vivo and in vitro.British journal of pharmacology · 2007Article
- Vascular effects of anandamide and N-acylvanillylamines in the human forearm and skin microcirculation.British journal of pharmacology · 2005Article
- Central and peripheral components of the pressor effect of anandamide in urethane-anaesthetized rats.British journal of pharmacology · 2005Article
- Cardiovascular pharmacology of cannabinoids.Handbook of experimental pharmacology · 2005Review
- The cannabinomimetic arachidonyl-2-chloroethylamide (ACEA) acts on capsaicin-sensitive TRPV1 receptors but not cannabinoid receptors in rat joints.British journal of pharmacology · 2004Article
- The complexities of the cardiovascular actions of cannabinoids.British journal of pharmacology · 2004Review
- Hypotensive effect of anandamide through the activation of CB1 and VR1 spinal receptors in urethane-anesthetized rats.Naunyn-Schmiedeberg's archives of pharmacology · 2003Article
- Cannabinoid receptor activation in the rostral ventrolateral medulla oblongata evokes cardiorespiratory effects in anaesthetised rats.British journal of pharmacology · 2003Article
- 'Entourage' effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism.British journal of pharmacology · 2002Article
- B1-kinin receptors modulateIndian journal of pharmacologyArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
1. We tested the hypothesis that sensory nerves innervating blood vessels play a role in the local and systemic regulation of the cardiovascular and respiratory (CVR) systems. We measured CVR reflexes evoked by administration of anandamide (86 - 863 nmoles) and capsaicin (0.3 - 10 nmoles) into the hindlimb vasculature of anaesthetized rats. 2. Anandamide and capsaicin each caused a rapid dose-dependent reflex fall in blood pressure and an increase in ventilation when injected intra-arterially into the hindlimb. 3. Action of both agonists at the vanilloid receptor (VR1) on perivascular sensory nerves was investigated using capsazepine (1 mg kg(-1) i.a.) a competitive VR1 antagonist, ruthenium red (1 mg kg(-1) i.a.), a non-competitive antagonist at VR1, or a desensitizing dose of capsaicin (200 nmoles i.a.). The cannabinoid receptor antagonist SR141716 (1 mg kg(-1) i.a.) was used to determine agonist activity at the CB(1) receptor. 4. Capsazepine, ruthenium red, or acute VR1 desensitization by capsaicin-pretreatment, markedly attenuated the reflex CVR responses evoked by anandamide and capsaicin (P< 0.05; paired Student's t-test). Blockade of CB(1) had no significant effect on the responses to anandamide. 5. Local sectioning of the femoral and sciatic nerves attenuated CVR responses to anandamide and capsaicin (P< 0.05). Vagotomy or carotid sinus sectioning had no significant effect on anandamide- or capsaicin-induced responses. 6. These data demonstrate that both the endogenous cannabinoid, anandamide, and the vanilloid, capsaicin, evoke CVR reflexes when injected intra-arterially into the rat hindlimb. These responses appear to be mediated reflexly via VR1 located on sensory nerve endings within the hindlimb vasculature.
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